Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, China.
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110112, China.
Future Oncol. 2016 Sep;12(18):2127-34. doi: 10.2217/fon-2016-0233. Epub 2016 Jun 21.
Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.
幽门螺杆菌（H. pylori）是胃癌的明确致癌物。H. pylori 感染会引起慢性炎症，导致基因的 DNA 损伤和异常甲基化，这些途径参与了 H. pylori 相关的胃癌发生。这些途径中涉及的基因的多态性可能会改变胃癌的易感性。在这篇综述中，我们重点关注了这些基因的多态性对胃癌易感性的作用，特别强调了它们与 H. pylori 感染的可能相互作用。我们发现，许多关于这一主题的研究并没有同时报告 H. pylori 感染和相互作用的情况，结果仍不确定。
