幽门螺杆菌相关胃癌的分子发病机制
Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer.
作者信息
Shimizu Takahiro, Marusawa Hiroyuki, Watanabe Norihiko, Chiba Tsutomu
机构信息
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
出版信息
Gastroenterol Clin North Am. 2015 Sep;44(3):625-38. doi: 10.1016/j.gtc.2015.05.011. Epub 2015 Jul 7.
Helicobacter pylori infection plays a crucial role in gastric carcinogenesis. H pylori exerts oncogenic effects on gastric mucosa through complex interaction between bacterial virulence factors and host inflammatory responses. On the other hand, gastric cancer develops via stepwise accumulation of genetic and epigenetic alterations in H pylori-infected gastric mucosa. Recent comprehensive analyses of gastric cancer genomes indicate a multistep process of genetic alterations as well as possible molecular mechanisms of gastric carcinogenesis. Both genetic processes of gastric cancer development and molecular oncogenic pathways related to H pylori infection are important to completely understand the pathogenesis of H pylori-related gastric cancer.
幽门螺杆菌感染在胃癌发生过程中起着关键作用。幽门螺杆菌通过细菌毒力因子与宿主炎症反应之间的复杂相互作用，对胃黏膜产生致癌作用。另一方面，胃癌是通过幽门螺杆菌感染的胃黏膜中基因和表观遗传改变的逐步积累而发展的。最近对胃癌基因组的全面分析表明了基因改变的多步骤过程以及胃癌发生的可能分子机制。胃癌发展的遗传过程和与幽门螺杆菌感染相关的分子致癌途径对于全面了解幽门螺杆菌相关胃癌的发病机制都很重要。
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