脑膜炎球菌双伙伴分泌系统及其与脑膜炎患者预后的关联。
Meningococcal Two-Partner Secretion Systems and Their Association with Outcome in Patients with Meningitis.
作者信息
Piet Jurgen R, van Ulsen Peter, Ur Rahman Sadeeq, Bovenkerk Sandra, Bentley Stephen D, van de Beek Diederik, van der Ende Arie
机构信息
Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center (AMC), Amsterdam, the Netherlands Department of Medical Microbiology, Academic Medical Center (AMC), Amsterdam, the Netherlands.
Section of Molecular Microbiology, Department of Molecular Cell Biology, Vrije Universiteit, Amsterdam, the Netherlands.
出版信息
Infect Immun. 2016 Aug 19;84(9):2534-40. doi: 10.1128/IAI.00160-16. Print 2016 Sep.
Two-partner secretion (TPS) systems export large TpsA proteins to the surface and extracellular milieu. In meningococci, three different TPS systems exist, and of these, TPS system 2 (TPS2) and TPS3 can be detected by the host's immune system. We evaluated the distribution of TPS systems among clinical isolates from two prospective cohort studies comprising 373 patients with meningococcal meningitis. TPS system 1 was present in 91% of isolates, and system 2 and/or 3 was present in 67%. The TPS system distribution was related to clonal complexes. Infection with strains with TPS2 and/or TPS3 resulted in less severe disease and better outcomes than infection with strains without these systems. Using whole-blood stimulation experiments, we found no differences in the host cytokine response between patients infected with TPS system 2 and 3 knockout strains and patients infected with a wild-type strain. In conclusion, meningococcal TPS system 2 and/or 3 is associated with disease severity and outcome in patients with meningitis.
双组分分泌（TPS）系统可将大型TpsA蛋白输出至表面及细胞外环境。在脑膜炎奈瑟菌中，存在三种不同的TPS系统，其中，TPS系统2（TPS2）和TPS3可被宿主免疫系统检测到。我们通过两项前瞻性队列研究，对373例脑膜炎奈瑟菌性脑膜炎患者的临床分离株中TPS系统的分布情况进行了评估。91%的分离株存在TPS系统1，67%的分离株存在系统2和/或3。TPS系统分布与克隆复合体相关。与感染无这些系统菌株的患者相比，感染有TPS2和/或TPS3菌株的患者病情较轻，预后较好。通过全血刺激实验，我们发现感染TPS系统2和3基因敲除菌株的患者与感染野生型菌株的患者在宿主细胞因子反应方面没有差异。总之，脑膜炎奈瑟菌TPS系统2和/或3与脑膜炎患者的疾病严重程度及预后相关。
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