Panzarino Michele, Gravina Angela, Carosi Veronica, Crobeddu Patrizio, Tiroli Alessia, Lombardi Roberto, D'Ottavio Stefano, Galante Alberto, Legramante Jacopo M
Advanced Technology in Rehabilitation Medicine, Università "Tor Vergata", via Montpellier 1, 00133, Rome, Italy.
Corso di Scienze Motorie, Università "Tor Vergata", via Montpellier 1, 00133, Rome, Italy.
Aging Clin Exp Res. 2017 Jun;29(3):419-426. doi: 10.1007/s40520-016-0598-2. Epub 2016 Jun 20.
Aging is characterized by a physiological reduction in physical activity, which is inversely correlated with survival.
Aim of the present study is to evaluate the cardiovascular, central hemodynamic and autonomic responses to a single bout of adapted physical exercise in octogenarian subjects.
We studied cardiovascular, hemodynamic and autonomic responses to adapted physical activity in 33 subjects by a noninvasive methodology (Nexfin, Edwards Lifesciences Corporation).
Our octogenarians presented a significant increase in mean arterial pressure (p < 0.01) and heart rate (p < 0.005) in response to exercise, while both are reduced during the early recovery phase. Central hemodynamic showed a significant increase in stroke volume (p < 0.05), cardiac output (p < 0.01) and left ventricle contractility index (p < 0.01), whereas systemic vascular resistance showed a significant decrease (p < 0.001). We found a reduction in baroreflex control of the sinus node during exercise.
Our data demonstrate that in very old people adapted physical activity is able to activate cardiovascular system and to induce a postexercise hypotension similarly to adults. The baroreflex control of sinus node seems to contribute in the physiological mechanism of these cardiovascular adaptations.
In very old people, physical activity induces cardiovascular and hemodynamic responses not significantly different from those induced in adult even though some cautions particularly in the early recovery phase after exercise should be exercised.
衰老的特征是身体活动出现生理性减少，而身体活动与生存率呈负相关。
本研究的目的是评估八旬老人单次适应性体育锻炼后的心血管、中心血流动力学和自主神经反应。
我们采用非侵入性方法（Nexfin，爱德华兹生命科学公司）研究了33名受试者对适应性体育活动的心血管、血流动力学和自主神经反应。
我们的八旬老人在运动时平均动脉压（p < 0.01）和心率（p < 0.005）显著升高，而在恢复早期两者均降低。中心血流动力学显示，每搏输出量（p < 0.05）、心输出量（p < 0.01）和左心室收缩指数（p < 0.01）显著增加，而全身血管阻力显著降低（p < 0.001）。我们发现运动期间窦房结的压力反射控制降低。
我们的数据表明，在高龄老人中，适应性体育活动能够激活心血管系统，并像成年人一样诱发运动后低血压。窦房结的压力反射控制似乎在这些心血管适应的生理机制中起作用。
在高龄老人中，体育活动诱发的心血管和血流动力学反应与成年人诱发的反应无显著差异，尽管在运动后的早期恢复阶段应特别注意。
