2015年荷马·W·史密斯奖：足细胞从边缘走向中心舞台
2015 Homer W. Smith Award: The Podocyte from Periphery to Center Stage.
作者信息
Kerjaschki Dontscho
机构信息
Clinical Department of Pathology, Medical University of Vienna, Vienna, Austria
出版信息
J Am Soc Nephrol. 2016 Nov;27(11):3266-3270. doi: 10.1681/ASN.2016040490. Epub 2016 Jun 20.
Abstract
This overview summarizes selected major developments over the last 40 years in understanding podocyte biology and its involvement in glomerular disease subjectively from my perspective. Serendipity has played a major role in my contributions to investigative nephrology that range from basic mechanisms of immune deposit formation in experimental membranous nephropathy to the role of a microRNA in FSGS. This review emphasizes the importance of continuous reality checks of experimental results obtained in vitro or with genetically modified animals with human disease.
摘要
本综述从我的视角主观总结了过去40年里在理解足细胞生物学及其在肾小球疾病中的作用方面的一些主要进展。机缘巧合在我对肾脏研究的贡献中发挥了重要作用，这些贡献涵盖了从实验性膜性肾病中免疫沉积物形成的基本机制到微小RNA在局灶节段性肾小球硬化中的作用等多个方面。本综述强调了对体外或基因改造动物实验结果与人类疾病进行持续现实检验的重要性。
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MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype.微小RNA-193a调控人壁层上皮细胞向足细胞表型的转分化
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Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.局灶节段性肾小球硬化症是由 microRNA-193a 及其对 WT1 的下调诱导的。
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