小GTP酶Rab3a介导的质膜修复

Plasma membrane repairs by small GTPase Rab3a.

作者信息

Raiborg Camilla, Stenmark Harald

机构信息

Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.

出版信息

J Cell Biol. 2016 Jun 20;213(6):613-5. doi: 10.1083/jcb.201606006.

DOI:10.1083/jcb.201606006

PMID:27325788

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4915196/

Abstract

Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane repair.

摘要

溶酶体与质膜融合以帮助修复膜损伤，但其如何定位在这些损伤附近尚未完全明确。现在，恩卡尔纳ção等人（2016年。《细胞生物学杂志》。http://dx.doi.org/10.1083/jcb.201511093）证明，溶酶体GTP酶Rab3a及其效应器协调溶酶体定位和质膜修复。