• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

溶酶体在细胞的外围区域中处于松弛状态。

Lysosomes relax in the cellular suburbs.

作者信息

Gowrishankar Swetha, Ferguson Shawn M

机构信息

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510 Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510 Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510

出版信息

J Cell Biol. 2016 Mar 14;212(6):617-9. doi: 10.1083/jcb.201602082.

DOI:10.1083/jcb.201602082
PMID:26975848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4792081/
Abstract

Lysosomes support cellular homeostasis by degrading macromolecules and recycling nutrients. In this issue, Johnson et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507112) reveal a heterogeneity in lysosomal pH and degradative ability that correlates with lysosome subcellular localization, raising questions about the functional implications and mechanisms underlying these observations.

摘要

溶酶体通过降解大分子和循环利用营养物质来维持细胞内稳态。在本期杂志中，约翰逊等人（2016年。《细胞生物学杂志》。http://dx.doi.org/10.1083/jcb.201507112）揭示了溶酶体pH值和降解能力的异质性，这种异质性与溶酶体的亚细胞定位相关，这引发了关于这些观察结果的功能意义和潜在机制的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700b/4792081/0728a2a7f214/JCB_201602082_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700b/4792081/0728a2a7f214/JCB_201602082_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700b/4792081/0728a2a7f214/JCB_201602082_Fig1.jpg

相似文献

1
Lysosomes relax in the cellular suburbs.溶酶体在细胞的外围区域中处于松弛状态。
J Cell Biol. 2016 Mar 14;212(6):617-9. doi: 10.1083/jcb.201602082.
2
Plasma membrane repairs by small GTPase Rab3a.小GTP酶Rab3a介导的质膜修复
J Cell Biol. 2016 Jun 20;213(6):613-5. doi: 10.1083/jcb.201606006.
3
Probing the depths of cellular senescence.探测细胞衰老的深度。
J Cell Biol. 2013 Jul 8;202(1):11-3. doi: 10.1083/jcb.201305155. Epub 2013 Jul 1.
4
A painful TR(i)P to lysosomes.一趟通向溶酶体的痛苦之旅。
J Cell Biol. 2016 Nov 7;215(3):309-312. doi: 10.1083/jcb.201610067. Epub 2016 Oct 31.
5
Presenilins: a novel link between intracellular calcium signaling and lysosomal function?早老素：细胞内钙离子信号与溶酶体功能之间的新联系？
J Cell Biol. 2012 Jul 9;198(1):7-10. doi: 10.1083/jcb.201206003.
6
Neuronal endosomes to lysosomes: A journey to the soma.神经元内体到溶酶体：走向胞体的旅程。
J Cell Biol. 2018 Sep 3;217(9):2977-2979. doi: 10.1083/jcb.201806139. Epub 2018 Aug 16.
7
The noodle defense.面条防御。
J Cell Biol. 2013 Dec 23;203(6):871-3. doi: 10.1083/jcb.201310128.
8
Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular.溶酶体胞吐作用、外泌体释放和分泌自噬：自噬和内溶酶体系统向细胞外延伸。
Int J Mol Sci. 2020 Apr 8;21(7):2576. doi: 10.3390/ijms21072576.
9
Lysosome biogenesis: Regulation and functions.溶酶体生物发生：调控与功能。
J Cell Biol. 2021 Jun 7;220(6). doi: 10.1083/jcb.202102001. Epub 2021 May 5.
10
The lysosome: from waste bag to potential therapeutic target.溶酶体：从垃圾袋到潜在治疗靶点。
J Mol Cell Biol. 2013 Aug;5(4):214-26. doi: 10.1093/jmcb/mjt022.

引用本文的文献

1
Neurofilament accumulation disrupts autophagy in giant axonal neuropathy.神经丝积聚破坏巨大轴索性神经病中的自噬。
JCI Insight. 2025 Mar 10;10(5):e177999. doi: 10.1172/jci.insight.177999.
2
Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration.诱导多能干细胞模型中额颞叶变性的蛋白质稳态缺陷。
Transl Psychiatry. 2022 Dec 10;12(1):508. doi: 10.1038/s41398-022-02274-5.
3
The Wnt/Beta-Catenin Pathway and Cytoskeletal Filaments Are Involved in the Positioning, Size, and Function of Lysosomes during Chick Myogenesis.

本文引用的文献

1
The position of lysosomes within the cell determines their luminal pH.溶酶体在细胞内的位置决定了其腔室的pH值。
J Cell Biol. 2016 Mar 14;212(6):677-92. doi: 10.1083/jcb.201507112.
2
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.在阿尔茨海默病淀粉样斑块处，管腔蛋白酶缺陷型轴突溶酶体大量积聚。
Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3699-708. doi: 10.1073/pnas.1510329112. Epub 2015 Jun 29.
3
Beyond indigestion: emerging roles for lysosome-based signaling in human disease.
Wnt/β-连环蛋白通路和细胞骨架丝参与了鸡肌发生过程中溶酶体的定位、大小和功能。
Cells. 2022 Oct 27;11(21):3402. doi: 10.3390/cells11213402.
4
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy.细胞质体的核内侵入伴随着自噬作用的增强。
Life Sci Alliance. 2022 May 13;5(9). doi: 10.26508/lsa.202101160. Print 2022 Sep.
5
Heterogeneity of ferrous iron-containing endolysosomes and effects of endolysosome iron on endolysosome numbers, sizes, and localization patterns.含铁内溶酶体的异质性及内溶酶体铁对内溶酶体数量、大小和定位模式的影响。
J Neurochem. 2022 Apr;161(1):69-83. doi: 10.1111/jnc.15583. Epub 2022 Feb 23.
6
Distinct retrograde microtubule motor sets drive early and late endosome transport.两种逆行微管马达分别驱动早期和晚期内涵体运输。
EMBO J. 2020 Dec 15;39(24):e103661. doi: 10.15252/embj.2019103661. Epub 2020 Nov 20.
7
Deregulation of signalling in genetic conditions affecting the lysosomal metabolism of cholesterol and galactosyl-sphingolipids.遗传条件下信号转导失调会影响胆固醇和半乳糖鞘脂的溶酶体代谢。
Neurobiol Dis. 2020 Dec;146:105142. doi: 10.1016/j.nbd.2020.105142. Epub 2020 Oct 17.
8
Molecular Mechanisms of Lysosome and Nucleus Communication.溶酶体与核通讯的分子机制
Trends Biochem Sci. 2020 Nov;45(11):978-991. doi: 10.1016/j.tibs.2020.06.004. Epub 2020 Jul 2.
9
Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs.吲哚美辛通过诱导胃癌细胞溶酶体功能障碍来破坏自噬通量，并增加其对细胞毒性药物的敏感性。
Sci Rep. 2018 Feb 26;8(1):3593. doi: 10.1038/s41598-018-21455-1.
10
L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease.L-亮氨酸和 SPNS1 协同改善了小鼠和人类尼曼-匹克 C 型疾病中的自噬功能障碍。
Sci Rep. 2017 Nov 21;7(1):15944. doi: 10.1038/s41598-017-15305-9.
消化不良之外：基于溶酶体的信号传导在人类疾病中的新作用
Curr Opin Cell Biol. 2015 Aug;35:59-68. doi: 10.1016/j.ceb.2015.04.014. Epub 2015 May 15.
4
Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes.轴突自噬体通过与晚期内体融合招募动力蛋白进行逆行运输。
J Cell Biol. 2015 May 11;209(3):377-86. doi: 10.1083/jcb.201412046. Epub 2015 May 4.
5
Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting.Lrp1/低密度脂蛋白受体在不依赖甘露糖6-磷酸的溶酶体酶靶向过程中起关键作用。
Traffic. 2015 Jul;16(7):743-59. doi: 10.1111/tra.12284. Epub 2015 Apr 27.
6
Lysosomal storage diseases: from pathophysiology to therapy.溶酶体贮积症：从病理生理学到治疗。
Annu Rev Med. 2015;66:471-86. doi: 10.1146/annurev-med-122313-085916.
7
RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.RILP通过与V1G1亚基相互作用来调节液泡ATP酶。
J Cell Sci. 2014 Jun 15;127(Pt 12):2697-708. doi: 10.1242/jcs.142604. Epub 2014 Apr 24.
8
hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.hVps41 和 VAMP7 介导溶酶体膜蛋白从 TGN 到晚期内体的直接运输。
Nat Commun. 2013;4:1361. doi: 10.1038/ncomms2360.
9
Lysosomal acidification mechanisms.溶酶体酸化机制。
Annu Rev Physiol. 2012;74:69-86. doi: 10.1146/annurev-physiol-012110-142317.
10
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.自噬体在原代神经元中从远端起始，并在向细胞体运输过程中成熟。
J Cell Biol. 2012 Feb 20;196(4):407-17. doi: 10.1083/jcb.201106120. Epub 2012 Feb 13.