Panahi Yunes, Pishgoo Bahram, Sahebkar Amirhossein
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Cardiology, Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Heart Views. 2015 Jul-Sep;16(3):85-7. doi: 10.4103/1995-705X.164462.
Heracleum persicum is a common dietary spice with several traditional medicinal properties important for cardiovascular health including antioxidant, hypolipidemic, and anti-inflammatory effects. This study explored the effects of supplementation with H. persicum fruit on the angiographic findings of patients with minimal coronary artery disease (CAD).
Subjects who were diagnosed with <50% stenosis in any of their coronary arteries by angiography were selected for this trial and randomly assigned to H. persicum hydroalcoholic fruit extract (n = 15; 300 mg/day) or placebo (n = 12) for 6 months. At the end of the trial, participants underwent a second coronary angiography in order to evaluate the progression of their disease.
Posttrial angiography did not reveal any improvement in the number of stenosed vessels after consumption of H. persicum extract versus placebo (P > 0.05). Similarly, there was no significant difference between the study groups in terms of disease progression and chest pain score (P > 0.05).
The present results do not support any clinically significant benefit of supplementation with H. persicum extract on the angiographic findings of in patients with minimal CAD.
波斯阿魏是一种常见的食用香料，具有多种对心血管健康重要的传统药用特性，包括抗氧化、降血脂和抗炎作用。本研究探讨了补充波斯阿魏果实对轻度冠状动脉疾病（CAD）患者血管造影结果的影响。
通过血管造影诊断为任何一支冠状动脉狭窄<50%的受试者被选入本试验，并随机分为波斯阿魏果实水醇提取物组（n = 15；300毫克/天）或安慰剂组（n = 12），为期6个月。试验结束时，参与者接受第二次冠状动脉造影以评估其疾病进展。
与安慰剂相比，服用波斯阿魏提取物后，试验后的血管造影未显示狭窄血管数量有任何改善（P>0.05）。同样，在疾病进展和胸痛评分方面，研究组之间也没有显著差异（P>0.05）。
目前的结果不支持补充波斯阿魏提取物对轻度CAD患者的血管造影结果有任何临床显著益处。
