Liu Liping, Jentoft Mark E, Boland Jennifer M
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.
Hum Pathol. 2016 Oct;56:109-13. doi: 10.1016/j.humpath.2016.05.019. Epub 2016 Jun 17.
Herein we present the case of a 42-year-old man who presented with an anterior mediastinal mass, which was found to represent a mature teratoma. Within it, there was a secondary somatic malignant glial neoplasm with mitotic activity and necrosis, compatible with glioblastoma. He experienced early local recurrence and lymph node metastasis, but is alive and well 3 1/2 years after diagnosis. Neither the teratoma nor the glioblastoma components had abnormalities of chromosome 12, which may implicate that this teratoma was more closely related to those arising along the midline of infants and children (type I germ cell tumor) than to the typically malignant testicular examples, which often contain mixed germ cell elements (type II germ cell tumor).
在此，我们报告一例42岁男性患者，其前纵隔肿物经检查为成熟畸胎瘤。在该畸胎瘤内，存在一个具有有丝分裂活性和坏死的继发性体部恶性胶质肿瘤，符合胶质母细胞瘤。他出现了早期局部复发和淋巴结转移，但在诊断后3年半仍存活且状况良好。畸胎瘤和胶质母细胞瘤成分均无12号染色体异常，这可能意味着该畸胎瘤与婴幼儿中线部位发生的畸胎瘤（I型生殖细胞肿瘤）关系更为密切，而非与通常含有混合生殖细胞成分的典型恶性睾丸畸胎瘤（II型生殖细胞肿瘤）关系密切。
