Department of Uro-oncology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, 5, Roentgen Street, 02-781, Warsaw, Poland.
Med Oncol. 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3.
Testicular teratomas represent a specific entity within the group of germ-cell tumours. They may comprise elements of all three germ layers. In contrast to prepubertal benign teratomas observed in infants and adolescents, postpubertal teratomas originate from the malignant germ-cell precursor. Given the good prognosis and curability of most patients with germ-cell tumour, medical oncologists and urological surgeons must be well acquainted with the principles of teratomas management. Surgery plays the decisive part in teratomas treatment, as these tumours are resistant to radio- and, to some extent, chemotherapy. In this article we concentrate on the management of post-chemotherapy resection of teratomatous masses, with special attention to the phenomenon of 'growing teratoma syndrome' and somatic-type transformation of teratomas. To understand the nature of teratomas better, we begin with a glimpse of their biological, molecular and immunohistochemical features. Managing germ-cell tumours, teratomas in particular, in high-volume reference centres is of utmost importance to maintain and increase the survivorship rate in these patients.
睾丸生殖细胞瘤是生殖细胞肿瘤中的一个特殊实体。它们可能包含所有三个胚层的成分。与婴儿和青少年中观察到的青春期前良性生殖细胞瘤不同，青春期后生殖细胞瘤源自恶性生殖细胞前体。鉴于大多数生殖细胞瘤患者的预后和可治愈性良好，肿瘤内科医生和泌尿外科医生必须熟悉生殖细胞瘤管理原则。手术在生殖细胞瘤的治疗中起着决定性的作用，因为这些肿瘤对放射治疗和一定程度的化疗有抗性。在本文中，我们专注于化疗后切除含生殖细胞瘤的肿块的管理，特别关注“生长性生殖细胞瘤综合征”和生殖细胞瘤的体瘤样转化现象。为了更好地了解生殖细胞瘤的性质，我们首先了解其生物学、分子和免疫组织化学特征。在高容量参考中心管理生殖细胞瘤，特别是生殖细胞瘤，对于维持和提高这些患者的生存率至关重要。
