Committees on Immunology and Cancer Biology, Department of Pathology, The University of Chicago, Chicago, Illinois, USA.
Nat Immunol. 2016 Jun 21;17(7):775-82. doi: 10.1038/ni.3481.
Innate lymphoid cells (ILCs) are a family of immune effector cells that have important roles in host defense, metabolic homeostasis and tissue repair but can also contribute to inflammatory diseases such as asthma and colitis. These cells can be categorized into three groups on the basis of the transcription factors that direct their function and the cytokines they produce, which parallel the effector functions of T lymphocytes. The hierarchy of cell-fate-restriction events that occur as common lymphoid progenitors become committed to each of the ILC lineages further underscores the relationship between these innate immune cells and T lymphocytes. In this Review we discuss the developmental program of ILCs and transcription factors that guide ILC lineage specification and commitment.
先天淋巴细胞（ILC）是一类免疫效应细胞，它们在宿主防御、代谢稳态和组织修复中发挥着重要作用，但也可能导致哮喘和结肠炎等炎症性疾病。这些细胞可以根据指导其功能的转录因子和产生的细胞因子分为三组，与 T 淋巴细胞的效应功能相平行。当普通淋巴祖细胞成为每个 ILC 谱系的定向细胞时，细胞命运限制事件的层次结构进一步强调了这些先天免疫细胞与 T 淋巴细胞之间的关系。在这篇综述中，我们讨论了 ILC 的发育程序以及指导 ILC 谱系特化和定向的转录因子。
