Middlehurst R J, Pedlar J, Barker G R, Rood J P
Department of Oral and Maxillofacial Surgery, University of Manchester Dental Hospital, England.
J Oral Maxillofac Surg. 1989 Jul;47(7):672-3. doi: 10.1016/s0278-2391(89)80003-5.
The concentration of cephradine in serum and mandibular bone was assayed in 22 patients undergoing third molar surgery following a single 1-g intramuscular injection. Serum and cortical bone samples taken simultaneously contained mean cephradine concentrations of 12.41 micrograms/mL and 1.25 micrograms/g, respectively. These results, when compared with those reported for other bony sites, including femoral head and knee, show a reduced bone penetration with a bone-to-serum ratio of approximately 0.10:1.
对22例接受第三磨牙手术的患者单次肌内注射1克头孢拉定后，测定了血清和下颌骨中头孢拉定的浓度。同时采集的血清和皮质骨样本中头孢拉定的平均浓度分别为12.41微克/毫升和1.25微克/克。与其他骨部位（包括股骨头和膝盖）报告的结果相比，这些结果显示骨穿透率降低，骨与血清的比例约为0.10:1。
