Kimura Michio, Go Makiko, Iwai Mina, Usami Eiseki, Teramachi Hitomi, Yoshimura Tomoaki
1 Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
2 Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
J Oncol Pharm Pract. 2017 Sep;23(6):413-421. doi: 10.1177/1078155216655473. Epub 2016 Jun 20.
Introduction When rapid feedback to physicians must be provided, e.g. monitoring therapy with the oral anticoagulant warfarin or providing therapeutic support for patients undergoing cancer chemotherapy, the involvement of pharmacists is required for outpatients. We launched a pharmacist outpatient service for patients with cancer taking oral anti-cancer agents. We evaluated the role and usefulness of the pharmacist outpatient service for these patients undergoing oral monotherapy with anti-cancer agents. Methods Data regarding prescription recommendations were collected from the drug management guidance records of 154 patients who consulted the pharmacist outpatient service between July 2013 and September 2015. In addition, the rates of prescription recommendation adherence were calculated. Between April and August 2015, a self-reported questionnaire was administered to 47 patients undergoing therapy with oral anti-cancer agents who were visiting the pharmacist outpatient service at the Ogaki Municipal Hospital (Ogaki, Japan). Results Prescription recommendations were given to 235 cases. The total rate of adherence to the prescription recommendations was 94.9% (223/235 cases). The majority of prescription recommendations regarding supportive care were those for moisturizing agents (20.9%), analgesics (20.9%), steroid ointments (12.7%), and antihypertensive agents (10.8%). When continued guidance was provided, significant changes were observed for survey items 3 (knowing the side effects of the medication), 8 (worrying about side effects), and 12 (interest in prescribed medicine) ( p = 0.0049, p < 0.0001, and p = 0.0164, respectively). Conclusion Our study showed that continued pharmaceutical intervention resulted in a deeper understanding of the medications' side effects, and it reduced anxiety levels in patients undergoing monotherapy with oral anti-cancer agents.
引言 当必须向医生提供快速反馈时，例如监测口服抗凝剂华法林的治疗情况或为接受癌症化疗的患者提供治疗支持，门诊患者需要药剂师的参与。我们为服用口服抗癌药的癌症患者推出了药剂师门诊服务。我们评估了药剂师门诊服务对这些接受口服抗癌药单一疗法患者的作用和实用性。方法 从2013年7月至2015年9月咨询药剂师门诊服务的154例患者的药物管理指导记录中收集有关处方建议的数据。此外，计算了处方建议的依从率。2015年4月至8月，对47例在日本大垣市立医院药剂师门诊接受口服抗癌药治疗的患者进行了自我报告问卷调查。结果 共给出235例处方建议。处方建议的总依从率为94.9%（223/235例）。关于支持性护理的大多数处方建议是针对保湿剂（20.9%）、镇痛药（20.9%）、类固醇软膏（12.7%）和抗高血压药（10.8%）。当提供持续指导时，调查项目3（了解药物副作用）、8（担心副作用）和12（对处方药的兴趣）有显著变化（p分别为0.0049、p<0.0001和p=0.0164）。结论 我们的研究表明，持续的药学干预使患者对药物副作用有了更深入的了解，并降低了接受口服抗癌药单一疗法患者的焦虑水平。
