Stimulatory effects of short-chain fatty acids on colonic absorption in newborn piglets in vivo.

This study examined the absorption of short-chain fatty acids (SCFA) and their effects on colonic conservation of water and sodium. Newborn York piglets, 2-23 days of age and exclusively suckled, were studied comparing absorption from a control/electrolyte solution with that from a SCFA solution. The results indicated that SCFA absorption is highest at birth, with a rapid decline over 72 h to a lower and relatively stable level. During the control perfusions, water and sodium absorption increased with age. The addition of SCFA to the perfusate stimulated both water and sodium uptake in the first 2 weeks. After the 14th day, sodium absorption continued to be enhanced by SCFA, but water movement remained unchanged from control levels. Right and left colon responses were similar. The results suggest that although luminal SCFA levels may be limited early in life, the presence of SCFA has stimulatory effects on the absorption of sodium and water from the colon in newborns.