Murray R D, McClung H J, Li B U, Ailabouni A
Division of Gastroenterology, Columbus Children's Hospital, OH 43205.
J Pediatr Gastroenterol Nutr. 1989 Jan;8(1):95-101. doi: 10.1097/00005176-198901000-00018.
This study examined the absorption of short-chain fatty acids (SCFA) and their effects on colonic conservation of water and sodium. Newborn York piglets, 2-23 days of age and exclusively suckled, were studied comparing absorption from a control/electrolyte solution with that from a SCFA solution. The results indicated that SCFA absorption is highest at birth, with a rapid decline over 72 h to a lower and relatively stable level. During the control perfusions, water and sodium absorption increased with age. The addition of SCFA to the perfusate stimulated both water and sodium uptake in the first 2 weeks. After the 14th day, sodium absorption continued to be enhanced by SCFA, but water movement remained unchanged from control levels. Right and left colon responses were similar. The results suggest that although luminal SCFA levels may be limited early in life, the presence of SCFA has stimulatory effects on the absorption of sodium and water from the colon in newborns.
本研究检测了短链脂肪酸（SCFA）的吸收及其对结肠水和钠保留的影响。对2至23日龄、纯母乳喂养的新生约克仔猪进行了研究，比较了对照/电解质溶液与SCFA溶液的吸收情况。结果表明，SCFA吸收在出生时最高，在72小时内迅速下降至较低且相对稳定的水平。在对照灌注期间，水和钠的吸收随年龄增加。在前两周，向灌注液中添加SCFA刺激了水和钠的摄取。第14天后，SCFA继续增强钠的吸收，但水的转运与对照水平相比保持不变。左右结肠的反应相似。结果表明，尽管生命早期管腔内SCFA水平可能有限，但SCFA的存在对新生儿结肠钠和水的吸收具有刺激作用。
