激活素与抑制素：在发育、生理学及疾病中的作用
Activins and Inhibins: Roles in Development, Physiology, and Disease.
作者信息
Namwanje Maria, Brown Chester W
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030 Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030 Texas Children's Hospital, Houston, Texas 77030.
出版信息
Cold Spring Harb Perspect Biol. 2016 Jul 1;8(7):a021881. doi: 10.1101/cshperspect.a021881.
Abstract
Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion and erythropoiesis, the TGF-β family members activin and inhibin have been shown to participate in a variety of biological processes, from the earliest stages of embryonic development to highly specialized functions in terminally differentiated cells and tissues. Herein, we present the history, structures, signaling mechanisms, regulation, and biological processes in which activins and inhibins participate, including several recently discovered biological activities and functional antagonists. The potential therapeutic relevance of these advances is also discussed.
摘要
自从最初作为促卵泡激素（FSH）分泌和红细胞生成的调节因子被发现以来，转化生长因子-β（TGF-β）家族成员激活素和抑制素已被证明参与了从胚胎发育的最早阶段到终末分化细胞和组织中高度特化功能的各种生物学过程。在此，我们介绍激活素和抑制素的历史、结构、信号传导机制、调节以及它们参与的生物学过程，包括一些最近发现的生物学活性和功能拮抗剂。还讨论了这些进展的潜在治疗意义。
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Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination.转化生长因子β（Tgfβ）和激活素配体的组合作用促进少突胶质细胞发育和中枢神经系统髓鞘形成。
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