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睾酮和17β-雌二醇调节雄性和雌性大鼠海马CA3区的尖波。

Testosterone and 17β-estradiol regulate hippocampal area CA3 sharp waves in male and female rats.

作者信息

Pearce Patrice, LaFrancois John J, Skucas Vanessa, Friedman Daniel, Fenton André A, Dvorak Dino, MacLusky Neil J, Scharfman Helen E

机构信息

The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; New York University Grossman School of Medicine, New York, NY 10016, USA.

The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

出版信息

Cell Rep. 2025 Jul 22;44(7):115952. doi: 10.1016/j.celrep.2025.115952. Epub 2025 Jul 8.

DOI:10.1016/j.celrep.2025.115952
PMID:40632653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12335218/
Abstract

Sharp wave-ripples (SPW-Rs) are critical to hippocampal function, and the same is true of gonadal steroids, but the interactions are unclear. We find that surgical removal of the gonads greatly reduces SPW rates in both sexes. Ripples are greatly reduced also. Testosterone treatment rescues SPW and ripple rates in males, and 17β-estradiol restores SPW rates in females. We also find that male SPW rates are higher than females but have less power. Furthermore, in intact females, SPW rates fluctuate with the stage of the ovarian cycle. These data demonstrate that hippocampal SPWs are significantly affected by gonadal removal, testosterone, and 17β-estradiol. In addition, there are sex differences. The data are consistent with past demonstrations that testosterone and 17β-estradiol play central roles in hippocampus and significantly expand the views of hormone action and SPW-Rs.

摘要

尖波涟漪（SPW-Rs）对海马体功能至关重要，性腺类固醇亦是如此，但它们之间的相互作用尚不清楚。我们发现，手术切除性腺会大幅降低两性的SPW发生率。涟漪也大幅减少。睾酮治疗可挽救雄性的SPW和涟漪发生率，而17β-雌二醇可恢复雌性的SPW发生率。我们还发现，雄性的SPW发生率高于雌性，但功率较小。此外，在未切除性腺的雌性中，SPW发生率随卵巢周期阶段而波动。这些数据表明，海马体的SPW受到性腺切除、睾酮和17β-雌二醇的显著影响。此外，还存在性别差异。这些数据与过去的研究结果一致，即睾酮和17β-雌二醇在海马体中起核心作用，并显著扩展了激素作用和SPW-Rs的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/df384eed3aa3/nihms-2099515-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/984fe4027997/nihms-2099515-f0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/c0c056f65a8d/nihms-2099515-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/a5541d5428eb/nihms-2099515-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/66c44065cdcf/nihms-2099515-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/df384eed3aa3/nihms-2099515-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/984fe4027997/nihms-2099515-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/7d337f637254/nihms-2099515-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/ff0e994942fd/nihms-2099515-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/c0c056f65a8d/nihms-2099515-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/a5541d5428eb/nihms-2099515-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/66c44065cdcf/nihms-2099515-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348e/12335218/df384eed3aa3/nihms-2099515-f0008.jpg

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The effect of estradiol add-back: a longitudinal MRI study in prostate cancer patients.雌二醇补充的效果：一项针对前列腺癌患者的纵向MRI研究
Endocr Connect. 2024 Feb 7;13(3). doi: 10.1530/EC-23-0409. Print 2024 Mar 1.
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Effects of testosterone replacement on lipid profile, hepatotoxicity, oxidative stress, and cognitive performance in castrated wistar rats.
睾酮替代治疗对去势 Wistar 大鼠血脂谱、肝毒性、氧化应激和认知功能的影响。
Arch Ital Urol Androl. 2023 Nov 15;95(4):11593. doi: 10.4081/aiua.2023.11593.
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Vortioxetine Reverses Impairment of Visuospatial Memory and Cognitive Flexibility Induced by Degarelix as a Model of Androgen Deprivation Therapy in Rats.伏硫西汀可逆转去势瑞林诱导的大鼠空间视觉记忆和认知灵活性损伤，去势瑞林作为大鼠雄激素剥夺疗法的模型。
Neuroendocrinology. 2024;114(3):279-290. doi: 10.1159/000535365. Epub 2023 Dec 16.
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Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus.强直性激活素信号主要在背侧海马体中塑造CA1神经元的细胞和突触特性。
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