血清血管紧张素II、激肽释放酶1水平及血管紧张素转换酶/激肽释放酶1基因多态性与冠状动脉狭窄所致急性心肌梗死的相关性
Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis.
作者信息
Dai Shu-hong, Li Ji-fu, Feng Jin-bo, Li Rui-jian, Li Chuan-bao, Li Zhuo, Zhang Yun, Li Da-qing
机构信息
The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China Department of cardiology, Qilu Hospital, Shandong University, China.
Department of obstetrics and gynecology, Qilu Hospital, Shandong University, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2016 Jun 21;17(2):1470320316655037. doi: 10.1177/1470320316655037. Print 2016 Apr-Jun.
INTRODUCTION
The study aims to confirm the association of acute myocardial infarction (AMI) with serum angiotensin II (AngII), kallikrein1 (KLK1), and ACE/KLK1 polymorphisms.
MATERIALS AND METHODS
Serum AngII/KLK1 levels and ACE and KLK1 genotypes were determined in 208 patients with AMI and 216 normal controls. Binary logistic regression was used for data analysis.
RESULTS
The differences in serum AngII levels were statistically significant between the groups. After adjusting for potential confounding factors, high serum levels of AngII and KLK1 significantly increased the risk of AMI. The individuals with ACE DD and KLK1 GG genotypes significantly increased the risk of AMI compared with those harboring the ACE II and KLK1 AA genotypes (OR = 8.77, 95% CI = 1.74-44.16).
CONCLUSIONS
(1) Increasing the serum levels of AngII increased the risk of AMI. (2) The risk of AMI increased significantly when the serum levels of AngII and KLK1 simultaneously increased. (3) Individuals with the combined genotypes of ACE DD and KLK1 GG showed significantly increased risk of AMI compared with those with the combined genotypes of ACE II and KLK1 AA.
引言
本研究旨在证实急性心肌梗死（AMI）与血清血管紧张素II（AngII）、激肽释放酶1（KLK1）以及ACE/KLK1基因多态性之间的关联。
材料与方法
测定了208例急性心肌梗死患者和216例正常对照者的血清AngII/KLK1水平以及ACE和KLK1基因型。采用二元逻辑回归进行数据分析。
结果
两组之间血清AngII水平差异具有统计学意义。在调整潜在混杂因素后，血清AngII和KLK1水平升高显著增加了急性心肌梗死的风险。与携带ACE II和KLK1 AA基因型的个体相比，携带ACE DD和KLK1 GG基因型的个体急性心肌梗死风险显著增加（OR = 8.77，95% CI = 1.74 - 44.16）。
结论
（1）血清AngII水平升高增加了急性心肌梗死的风险。（2）当血清AngII和KLK1水平同时升高时，急性心肌梗死风险显著增加。（3）与携带ACE II和KLK1 AA联合基因型的个体相比，携带ACE DD和KLK1 GG联合基因型的个体急性心肌梗死风险显著增加。
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