MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, 11519 Puerto Real, Spain.
Instituto de Investigación Biomédica de Cádiz (INiBICA), Hospital Uniersitario Puerta del Mar, Universidad de Cádiz, 11009 Cádiz, Spain.
Int J Environ Res Public Health. 2021 Mar 26;18(7):3443. doi: 10.3390/ijerph18073443.
There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults ( = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 ± 11.8 mmHg; ID: 116.7 ± 6.3 mmHg; II: 109.4 ± 12.3 mmHg, = 0.035) and body fat (DD: 27.3 ± 10.8%; ID: 22.6 ± 9.7%; II: 19.3 ± 7.1%, = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass ( = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 ± 3.0 vs. 6.5 ± 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 ± 2.3 vs. 7.6 ± 2.6 mg/kg/min). In conclusion, ACE I/D polymorphism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO.
关于 ACE I/D 多态性与健康之间的关系存在争议。本横断面研究纳入了 74 名健康成年人（=28 名女性；22.5±4.2 岁），旨在通过聚合酶链反应确定 ACE I/D 多态性（即腰围、体脂、血压（BP）、血糖、甘油三酯和炎症标志物）对心血管代谢风险、最大脂肪氧化（MFO）、心肺健康（最大摄氧量）、体力活动和饮食的影响。我们的结果显示，ACE I/D 多态性在收缩压（DD：116.4±11.8mmHg；ID：116.7±6.3mmHg；II：109.4±12.3mmHg，=0.035）和体脂（DD：27.3±10.8%；ID：22.6±9.7%；II：19.3±7.1%，=0.030）方面存在差异。有趣的是，我们还发现瘦体重相对化 MFO 存在基因型*性别交互作用（=0.048）。与 ID/II 多态性相比，DD 多态性在男性中具有更高的 MFO 值（8.4±3.0 与 6.5±2.9mg/kg/min），而 ID/II 多态性在女性中具有更高的 R-MFO 值（6.6±2.3 与 7.6±2.6mg/kg/min）。总之，ACE I/D 多态性与肥胖和 BP 明显相关，其中 II 基因型具有保护作用，但与心肺健康、饮食和体力活动无关。此外，我们的研究还强调，ACE I/D 基因多态性对 MFO 的影响存在性别二态性。
