Patriquin Michelle A, DeRamus Thomas, Libero Lauren E, Laird Angela, Kana Rajesh K
The Menninger Clinic, Houston, Texas.
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Birmingham, Alabama.
Hum Brain Mapp. 2016 Nov;37(11):3957-3978. doi: 10.1002/hbm.23288.
Social impairments in autism spectrum disorder (ASD), a hallmark feature of its diagnosis, may underlie specific neural signatures that can aid in differentiating between those with and without ASD. To assess common and consistent patterns of differences in brain responses underlying social cognition in ASD, this study applied an activation likelihood estimation (ALE) meta-analysis to results from 50 neuroimaging studies of social cognition in children and adults with ASD. In addition, the group ALE clusters of activation obtained from this was used as a social brain mask to perform surface-based cortical morphometry (SBM) in an empirical structural MRI dataset collected from 55 ASD and 60 typically developing (TD) control participants. Overall, the ALE meta-analysis revealed consistent differences in activation in the posterior superior temporal sulcus at the temporoparietal junction, middle frontal gyrus, fusiform face area (FFA), inferior frontal gyrus (IFG), amygdala, insula, and cingulate cortex between ASD and TD individuals. SBM analysis showed alterations in the thickness, volume, and surface area in individuals with ASD in STS, insula, and FFA. Increased cortical thickness was found in individuals with ASD, the IFG. The results of this study provide functional and anatomical bases of social cognition abnormalities in ASD by identifying common signatures from a large pool of neuroimaging studies. These findings provide new insights into the quest for a neuroimaging-based marker for ASD. Hum Brain Mapp 37:3957-3978, 2016. © 2016 Wiley Periodicals, Inc.
自闭症谱系障碍（ASD）中的社交障碍是其诊断的一个标志性特征，可能是有助于区分患有和未患有ASD者的特定神经特征的基础。为了评估ASD中社交认知背后大脑反应差异的常见和一致模式，本研究对50项关于ASD儿童和成人社交认知的神经影像学研究结果进行了激活可能性估计（ALE）元分析。此外，将由此获得的激活组ALE簇用作社交脑模板，在从55名ASD患者和60名正常发育（TD）对照参与者收集的经验性结构MRI数据集中进行基于表面的皮质形态测量（SBM）。总体而言，ALE元分析显示，ASD个体和TD个体在颞顶交界处的后颞上沟、额中回、梭状面孔区（FFA）、额下回（IFG）、杏仁核、岛叶和扣带回皮质的激活存在一致差异。SBM分析显示，ASD个体在颞上沟、岛叶和FFA的厚度、体积和表面积发生了改变。在ASD个体的额下回发现皮质厚度增加。本研究的结果通过从大量神经影像学研究中识别常见特征，为ASD社交认知异常提供了功能和解剖学基础。这些发现为寻找基于神经影像学的ASD标志物提供了新的见解。《人类大脑图谱》37:3957 - 3978，2016年。© 2016威利期刊公司。
