Wessmann A, Volk H A, Packer R M A, Ortega M, Anderson T J
Department of Neurology, Pride Veterinary Centre, Derby, UK.
Royal Veterinary College (RVC), London, UK.
Vet Rec. 2016 Sep 3;179(9):229. doi: 10.1136/vr.103355. Epub 2016 Jun 21.
Quality of life (QoL) plays a significant role in the treatment of dogs with idiopathic epilepsy (IE), yet is so far understudied. This study describes the outcome evaluation of an online questionnaire based on the carer's perception focusing on 62 QoL questions in 159 dogs with IE. Results showed that seizure frequency, but not seizure severity or presence of cluster seizures, was significantly associated with carer-perceived dog's QoL. Dogs receiving third-line antiepileptic drugs had a significantly lower perceived QoL than those that did not. Generalised linear mixed model analysis demonstrated that severity of the side effects sleeping more and ataxia were significantly associated with carer-perceived dog's QoL, with higher severities predicting lower QoL scores. The degree of carer acceptability of seizure frequency and severity was significantly associated with the dog's reported seizure frequency and severity. Moreover, there was a significant association between IE-related QoL changes of the dog and the carer, with reductions in perceived canine QoL scores associated with reductions in carer QoL, and vice versa. In conclusion, aspects of canine IE can affect both the carer and their dog's QoL. This has implications for the management and requires consideration when treatment options and outcomes are discussed.
生活质量（QoL）在特发性癫痫（IE）犬的治疗中起着重要作用，但迄今为止研究较少。本研究描述了一项基于照顾者认知的在线问卷的结果评估，该问卷聚焦于159只患有IE的犬的62个生活质量问题。结果显示，癫痫发作频率与照顾者感知的犬生活质量显著相关，而癫痫发作严重程度或丛集性发作的存在与之无关。接受三线抗癫痫药物治疗的犬的生活质量感知显著低于未接受该治疗的犬。广义线性混合模型分析表明，副作用（睡眠增多和共济失调）的严重程度与照顾者感知的犬生活质量显著相关，严重程度越高，生活质量得分越低。照顾者对癫痫发作频率和严重程度的接受程度与犬报告的癫痫发作频率和严重程度显著相关。此外，犬与照顾者的IE相关生活质量变化之间存在显著关联，犬生活质量感知得分的降低与照顾者生活质量的降低相关，反之亦然。总之，犬IE的各个方面会影响照顾者及其犬的生活质量。这对管理有影响，在讨论治疗方案和结果时需要考虑。
