Grant Kylie L, Long Sam N
Veterinary Referral Hospital, Melbourne, VIC, Australia.
Front Vet Sci. 2025 Mar 13;12:1518379. doi: 10.3389/fvets.2025.1518379. eCollection 2025.
Huperzine is a naturally occurring alkaloid derived from the Chinese clubmoss . It is a potent acetylcholinesterase inhibitor, among other properties, and has demonstrated protection against induced seizures in a mouse model of Dravet's syndrome as well as nerve-agent induced seizures and is being explored as a novel anticonvulsant in a human clinical trial for focal impaired awareness seizures. It is also being explored as a treatment for Alzheimer's, via neuroprotective effects and an ability to ameliorate neuroinflammation. Here we present a case series of 6 dogs with idiopathic epilepsy treated with huperzine to investigate this potential novel anticonvulsant. Despite a 50% drop out rate over the course of the study due to various causes including unexplained death, humane euthanasia and systemic disease, huperzine was generally well tolerated and showed some positive effects on demeanor. This study highlights the need for more research to investigate its efficacy as a novel antiepileptic medication in dogs.
石杉碱是一种从中国石松中提取的天然生物碱。它是一种强效的乙酰胆碱酯酶抑制剂，具有多种特性，在德雷维特综合征小鼠模型以及神经毒剂诱发的癫痫发作中均显示出对诱发癫痫的保护作用，目前正在一项针对局灶性意识障碍性癫痫发作的人体临床试验中作为一种新型抗惊厥药物进行探索。它还通过神经保护作用和改善神经炎症的能力，被探索用于治疗阿尔茨海默病。在此，我们展示了一个用石杉碱治疗6只特发性癫痫犬的病例系列，以研究这种潜在的新型抗惊厥药物。尽管在研究过程中由于各种原因，包括不明原因死亡、安乐死和全身性疾病，有50%的脱落率，但石杉碱总体耐受性良好，并对犬的行为表现出一些积极影响。这项研究强调需要更多研究来调查其作为犬类新型抗癫痫药物的疗效。
