Chen Yingdan, Yin Songchao, Li Meirong, Chen Rongzhang, Wei Ling, Ma Han, Deng Shuwen, de Hoog Gert Sybren, Lai Wei, Lu Chun, Feng Peiying
Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Shanghai Institute of Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Mycoses. 2016 Oct;59(10):662-7. doi: 10.1111/myc.12523. Epub 2016 Jun 22.
A first auricular case of chromoblastomycosis due to Fonsecaea nubica is reported in a 42-year-old Chinese male. He presented a slightly verrucous, erythematous plaque on his right auricle which had gradually extended over a 10-year period, and the patient reported a history of dog flea sting before onset of the lesions. Diagnosis was based on histopathological and mycological examination of clinical samples, which revealed muriform cells. Identification of the aetiological agent was assessed by morphological characteristics and confirmed at species level by sequencing of the rDNA internal transcribed spacer (ITS). The patient showed marked clinical improvement after 3 months combination therapy with itraconazole and terbinafine. The possible mode of transmission of auricular chromoblastomycosis is discussed.
报告了首例由暗产色霉引起的耳部着色芽生菌病病例,患者为一名42岁的中国男性。他的右耳出现了一个轻度疣状、红斑性斑块,该斑块在10年时间里逐渐扩大,患者报告在病变出现前有被狗蚤叮咬的病史。诊断基于临床样本的组织病理学和真菌学检查,结果显示有砖壁孢子。通过形态学特征评估病原体的鉴定,并通过rDNA内部转录间隔区(ITS)测序在种水平上进行确认。患者在接受伊曲康唑和特比萘芬联合治疗3个月后临床症状明显改善。本文还讨论了耳部着色芽生菌病可能的传播方式。