Hemeryck Lieselot Y, Vanhaecke Lynn
L.Y. Hemeryck and L. Vanhaecke are with the Laboratory of Chemical Analysis, Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Nutr Rev. 2016 Aug;74(8):475-89. doi: 10.1093/nutrit/nuw017. Epub 2016 Jun 20.
The human diet contributes significantly to the initiation and promotion of carcinogenesis. It has become clear that the human diet contains several groups of natural foodborne chemicals that are at least in part responsible for the genotoxic, mutagenic, and carcinogenic potential of certain foodstuffs. Electrophilic chemicals are prone to attack nucleophilic sites in DNA, resulting in the formation of altered nucleobases, also known as DNA adducts. Since DNA adduct formation is believed to signal the onset of chemically induced carcinogenesis, the DNA adduct-inducing potential of certain foodstuffs has been investigated to gain more insight into diet-related pathways of carcinogenesis. Many studies have investigated diet-related DNA adduct formation. This review summarizes work on known or suspected dietary carcinogens and the role of DNA adduct formation in hypothesized carcinogenesis pathways.
人类饮食在癌症发生的起始和促进过程中起着重要作用。现已明确，人类饮食中含有几类天然的食源化学物质，它们至少在一定程度上导致了某些食品的遗传毒性、致突变性和致癌潜力。亲电化学物质易于攻击DNA中的亲核位点，导致形成改变的核碱基，也称为DNA加合物。由于DNA加合物的形成被认为是化学诱导癌症发生的起始信号，因此人们对某些食品的DNA加合物诱导潜力进行了研究，以更深入了解与饮食相关的致癌途径。许多研究调查了与饮食相关的DNA加合物形成。本综述总结了关于已知或疑似饮食致癌物的研究工作，以及DNA加合物形成在假设的致癌途径中的作用。
