Carr C M, Chapatwala K D, Nandedkar A K
J Natl Med Assoc. 1989 Feb;81(2):137-9.
The incidence of sickle cell trait varies among blacks in North America. Although the average hemoglobin (Hb)-AS gene frequency is 8% in the United States, a value of 13.4% was recorded in South Carolina. Preliminary studies during a two-day community sponsored health fair in Selma, Alabama, revealed a sickle cell gene frequency of 15.96%. This study also found an intermediate frequency of 12.4% in a family practice center that is accredited for a residency program. Through a screening program, sickle cell trait was detected, a rigorous training program for resident physicians in family practice was implemented, and proper counseling to patients with hemoglobinopathies was provided. In the authors' judgment, laboratory screening for sickle cell trait is a first step toward genetic counseling and medical practice by family physicians and general practitioners.
镰状细胞性状的发病率在北美黑人中各不相同。尽管在美国，血红蛋白（Hb）-AS基因的平均频率为8%，但在南卡罗来纳州记录的值为13.4%。在阿拉巴马州塞尔玛市为期两天的社区赞助健康博览会上进行的初步研究显示，镰状细胞基因频率为15.96%。该研究还在一个获得住院医师培训项目认证的家庭医疗中心发现了12.4%的中间频率。通过一项筛查计划，检测出了镰状细胞性状，为家庭医疗住院医师实施了严格的培训计划，并为血红蛋白病患者提供了适当的咨询。作者认为，对镰状细胞性状进行实验室筛查是家庭医生和全科医生进行遗传咨询和医疗实践的第一步。
