Noronha P A, Honig G R
Pediatrics. 1979 Feb;63(2):242-6.
A number of hematologic disorders share diagnostic and clinical features of sickle cell anemia but have significantly different genetic implications and prognosis. Because of these differences, the establishment of a precise diagnosis is essential for the child in whom any form of sickle cell disease is identified. To illustrate the requirements for a definitive laboratory diagnosis of sickle cell anemia, this report presents the approach to establishing this diagnosis in two white American patients. From a review of the literature, these patients appear to be the only white Americans with sickle cell anemia in whom the diagnosis has been unequivocally established.
许多血液系统疾病具有镰状细胞贫血的诊断和临床特征，但在遗传影响和预后方面有显著差异。由于这些差异，对于确诊任何形式镰状细胞病的儿童而言，精确诊断至关重要。为说明镰状细胞贫血确定性实验室诊断的要求，本报告介绍了对两名美国白人患者进行该诊断的方法。从文献回顾来看，这两名患者似乎是仅有的确诊镰状细胞贫血的美国白人。
