髓系白血病中的有丝分裂活性。277例病例的研究。

Mitotic activity in myeloid leukaemias. A study of 277 cases.

作者信息

Sjögren U

出版信息

Scand J Haematol. 1978 Feb;20(2):159-67. doi: 10.1111/j.1600-0609.1978.tb02441.x.

DOI:10.1111/j.1600-0609.1978.tb02441.x

Abstract

The proportions of myeloblasts, promyelocytes, myelocytes and promonocytes within the granulopoietic precursor pool of the bone marrow and mitotic indices (MI) of the precursor cells were determined in 277 patients with various forms of myeloid leukaemias. The MI of the leukaemic patients were significantly lower than those of 20 normals. Thus the median MI in 186 cases of acute myeloid leukaemias was 0.68%, compared with 1.0% in 85 cases of chronic leukaemias and 1.2% in the normals. Separate MI of the different leukaemic precursor cells were counted in 21 cases of acute myeloid leukaemias and these indices were lower than those of the corresponding normal cells. There were significant differences between the different groups and subtypes of leukaemias and it is suggested that mitotic countings might be of diagnostic and prognostic significance.

摘要

在277例患有各种类型髓细胞白血病的患者中，测定了骨髓粒细胞生成前体细胞池中原始粒细胞、早幼粒细胞、中幼粒细胞和原单核细胞的比例以及前体细胞的有丝分裂指数（MI）。白血病患者的MI显著低于20名正常人。因此，186例急性髓细胞白血病的MI中位数为0.68%，而85例慢性白血病患者为1.0%，正常人为1.2%。在21例急性髓细胞白血病中对不同白血病前体细胞的MI进行了单独计数，这些指数低于相应的正常细胞。白血病的不同组和亚型之间存在显著差异，提示有丝分裂计数可能具有诊断和预后意义。