Itasaka M, Ikeda H, Yakuwa N, Kato S, Takahashi K, Yasui S
Kaku Igaku. 1989 Feb;26(2):189-94.
We studied the accumulated portion and the movement of I-123 IMP in the lung. Ten subjects were studied. They were four patients with fibrosing lung disease, two with lung cancer, and four with other lung disease. They underwent the broncho-alveolar lavage (BAL) for the diagnosis of their disease. 1.5 mCi of I-123 IMP was injected into the ante-cubital vein. The BAL examination was carried out about 40 minutes after the injection of I-123 IMP. The subjects' blood was sampled at the same time. The total BAL liquid (BAL-T) was divided into the fluid component (BAL-F) and the cell component (BAL-C) by centrifugation. The radioactivities in BAL-T, BAL-F, BAL-C, and serum (B-S) were measured by the well-counter. The average of BAL-T/B-S, BAL-F/B-S and BAL-C/B-S were 6.86, 4.26 and 2.71 respectively. It was confirmed that I-123 IMP was transported from the pulmonary capillary to the alveolar space and was taken up by the alveolar cells. It was considered that the analysis of the I-123 IMP release from the lung showed not only the endothelial cell uptake function but also the interstitial and material cells' amine transport and uptake function.
我们研究了 I-123 IMP 在肺内的积聚部位及移动情况。共对 10 名受试者进行了研究。其中包括 4 名肺纤维化疾病患者、2 名肺癌患者和 4 名其他肺部疾病患者。他们均接受了支气管肺泡灌洗（BAL）以明确病情诊断。向肘前静脉注射 1.5 mCi 的 I-123 IMP。在注射 I-123 IMP 约 40 分钟后进行 BAL 检查。同时采集受试者的血液样本。通过离心将总的 BAL 液体（BAL-T）分为液体成分（BAL-F）和细胞成分（BAL-C）。用井型计数器测量 BAL-T、BAL-F、BAL-C 和血清（B-S）中的放射性。BAL-T/B-S、BAL-F/B-S 和 BAL-C/B-S 的平均值分别为 6.86、4.26 和 2.71。证实 I-123 IMP 从肺毛细血管转运至肺泡腔并被肺泡细胞摄取。认为对 I-123 IMP 从肺释放情况的分析不仅显示了内皮细胞摄取功能，还显示了间质及实质细胞的胺转运和摄取功能。
