Kato K, Takahashi T, Yanagisawa T
Department of Radiology, Iwate Medical University.
Kaku Igaku. 1991 Apr;28(4):411-7.
In the experiment using guinea pigs, the accumulated portions of IMP after 125I-IMP microautoradiography were compared in a normal control group and a group exposed to cigarette smoke. In the smoke-exposed lung, the accumulation of silver grains were observed in the alveolar spaces and alveolar macrophages, as well as in the pulmonary capillaries and the alveolar epithelia. After the broncho-alveolar lavage (BAL), increases in alveolar macrophages, total counts of BAL fluid and counts of cell components were seen in the smoke-exposed lung. These results suggested that abnormal function of the pulmonary capillary or alveolar epithelium was wide spread in the smoke-exposed lung.
在使用豚鼠的实验中，比较了正常对照组和暴露于香烟烟雾的一组在125I-IMP微量放射自显影后IMP的累积部分。在暴露于烟雾的肺中，在肺泡腔、肺泡巨噬细胞以及肺毛细血管和肺泡上皮中观察到银颗粒的积累。支气管肺泡灌洗（BAL）后，暴露于烟雾的肺中肺泡巨噬细胞、BAL液总细胞数和细胞成分计数增加。这些结果表明，肺毛细血管或肺泡上皮的异常功能在暴露于烟雾的肺中广泛存在。
