Nakajima K, Toyama H, Ishikawa N, Hatakeyama R, Akisada M, Miyagawa S
Kaku Igaku. 1989 Feb;26(2):221-9.
Factor analysis was applied to dynamic study of Tc-99m MDP for the evaluation of hip joint disorders. Fifteen patients were examined; eight were normal, six were osteoarthritis in which one accompanied synovitis was included, and one was aseptic necrosis on the head of the femur. In normals, according to the Tc-99m MDP kinetics, three factor images and time-activity curves were obtained which were named as blood vessel, soft tissue, and bone factor images and curves. In the patient with osteoarthritis, increased accumulation of the hip joint was shown in bone factor image only. But in one patient, who took osteoarthritis with synovitis, marked accumulations of the Tc-99m MDP appeared not only on the bone factor image but also on the soft tissue. Operation revealed thickening synovial tissue around the hip joint, caused by inflammatory process. In follow-up studies of the patient with aseptic necrosis on the head of the left femur, excessive accumulations, which were seemed in his left hip joint on both bone and soft tissue factor images at first, were decreased respondently to the treatment of this lesion. In conclusion, the factor analysis was useful for differencial diagnosis of the hip joint disorders and observation of the clinical course of the hip joint disorders.
采用因子分析对锝-99m亚甲基二膦酸盐（Tc-99m MDP）进行动态研究，以评估髋关节疾病。对15例患者进行了检查；其中8例正常，6例为骨关节炎（包括1例伴有滑膜炎），1例为股骨头无菌性坏死。在正常情况下，根据Tc-99m MDP动力学，获得了三个因子图像和时间-活性曲线，分别命名为血管、软组织和骨因子图像及曲线。在骨关节炎患者中，仅在骨因子图像上显示髋关节的放射性摄取增加。但在1例伴有滑膜炎的骨关节炎患者中，Tc-99m MDP不仅在骨因子图像上，而且在软组织上均出现明显的放射性浓聚。手术显示髋关节周围滑膜组织增厚，由炎症过程引起。在对左侧股骨头无菌性坏死患者的随访研究中，最初在其左侧髋关节的骨和软组织因子图像上均出现的过度放射性浓聚，随着该病变的治疗而相应减少。总之，因子分析有助于髋关节疾病的鉴别诊断及观察髋关节疾病的临床病程。
