Takagi Hisato, Umemoto Takuya
Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan
Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan.
Diab Vasc Dis Res. 2016 Sep;13(5):341-7. doi: 10.1177/1479164116651389. Epub 2016 Jun 22.
To summarize the association of diabetes with abdominal aortic aneurysm rupture, we reviewed currently available studies with a systematic literature search and meta-analytic evaluation.
To identify all studies reporting the association of diabetes with abdominal aortic aneurysm rupture, MEDLINE and EMBASE were searched through July 2015. For each study, data regarding diabetes prevalence in both the ruptured and non-ruptured groups were used to generate an unadjusted odds ratio for abdominal aortic aneurysm rupture and 95% confidence intervals. Alternatively, an unadjusted or adjusted odds ratio, or hazard ratio for abdominal aortic aneurysm rupture with 95% confidence interval was directly abstracted (as available) from each individual study.
Our search identified 11 eligible studies. A primary meta-analysis of nine studies reporting data on ruptured (not including non-ruptured symptomatic) abdominal aortic aneurysm demonstrated that diabetes was associated with significantly lower prevalence/incidence of abdominal aortic aneurysm rupture (odds ratio/hazard ratio, 0.71; 95% confidence interval, 0.56 to 0.89; p = 0.003). A secondary meta-analysis of all 11 studies (adding two studies in which non-ruptured symptomatic abdominal aortic aneurysm was included in the rupture group) also demonstrated that diabetes was associated with significantly lower prevalence/incidence of abdominal aortic aneurysm rupture (odds ratio/hazard ratio, 0.77; 95% confidence interval, 0.63 to 0.95; p = 0.01).
Diabetes is negatively associated with abdominal aortic aneurysm rupture.
为总结糖尿病与腹主动脉瘤破裂之间的关联，我们通过系统的文献检索和荟萃分析评估，对当前可得的研究进行了回顾。
为识别所有报告糖尿病与腹主动脉瘤破裂关联的研究，我们检索了截至2015年7月的MEDLINE和EMBASE数据库。对于每项研究，使用破裂组和未破裂组中糖尿病患病率的数据，生成腹主动脉瘤破裂的未调整优势比及95%置信区间。或者，直接从每项单独研究中提取（如可得）腹主动脉瘤破裂的未调整或调整优势比，或风险比及95%置信区间。
我们的检索确定了11项符合条件的研究。对9项报告破裂腹主动脉瘤（不包括未破裂的有症状腹主动脉瘤）数据的研究进行的初步荟萃分析表明，糖尿病与腹主动脉瘤破裂的患病率/发病率显著降低相关（优势比/风险比，0.71；95%置信区间，0.56至0.89；p = 0.003）。对所有11项研究进行的二次荟萃分析（增加了两项将未破裂的有症状腹主动脉瘤纳入破裂组的研究）也表明，糖尿病与腹主动脉瘤破裂的患病率/发病率显著降低相关（优势比/风险比，0.77；95%置信区间，0.63至0.95；p = 0.01）。
糖尿病与腹主动脉瘤破裂呈负相关。
