Laganiere S, Yu B P
Department of Physiology, University of Texas, San Antonio 78284-7756.
Mech Ageing Dev. 1989 Jun;48(3):207-19. doi: 10.1016/0047-6374(89)90083-3.
To assess which membrane properties are modulated by the action of food restriction, characteristics of liver membrane structures of ad libitum-fed and food restricted Fischer 344 rats were analyzed over a wide age range. The results show that the yields of mitochondrial and microsomal membranes decreased in ad libitum-fed rats, but this age-related loss did not occur in food restricted rats until 30 months. Changes in membrane fatty acid composition which occurred with age were substantially modified by food restriction. Linoleic acid content progressively decreased in the membranes of ad libitum-fed rats with a concomitant increase of docosapentaenoic acid while an opposite pattern of change occurred in food restricted rats. Furthermore, food restriction maintained a low docosahexaenoic acid level in microsomes at all ages studied. While serum tocopherol increased markedly with age, there was little change in membrane tocopherol content in ad libitum-fed rats.
为了评估食物限制的作用会调节哪些膜特性，我们在较宽的年龄范围内分析了自由进食和食物受限的Fischer 344大鼠肝脏膜结构的特征。结果表明，自由进食大鼠的线粒体膜和微粒体膜产量下降，但这种与年龄相关的损失在食物受限大鼠中直到30个月才出现。随着年龄增长而发生的膜脂肪酸组成变化因食物限制而得到显著改变。自由进食大鼠膜中的亚油酸含量逐渐降低，同时二十二碳五烯酸增加，而食物受限大鼠则出现相反的变化模式。此外，在所有研究的年龄段，食物限制使微粒体中的二十二碳六烯酸水平保持在较低水平。虽然血清生育酚随年龄显著增加，但自由进食大鼠的膜生育酚含量变化不大。
