Mathewson Karen J, Van Lieshout Ryan J, Saigal Saroj, Morrison Katherine M, Boyle Michael H, Schmidt Louis A
McMaster University, Hamilton, Ontario, Canada.
Glob Pediatr Health. 2015 Jun 9;2:2333794X15589560. doi: 10.1177/2333794X15589560. eCollection 2015.
Autonomic functioning is altered in infants born at extremely low birth weight (ELBW; <1000 g), but we know little about how such alterations manifest in adulthood. We examined associations between birth weight and resting heart rate (R-R interval), high-frequency (HF) and low-frequency (LF) heart rate variability, and systolic (SBP) and diastolic (DBP) blood pressure, in 60 participants (ages 22-26) born at ELBW and free of major neurosensory impairment, and 79 controls born at normal birth weight (NBW; >2500 g). HF in the smallest-born ELBW participants was significantly lower than in NBW controls. In both groups, greater birth weight was associated with higher HF. Among ELBW survivors, lower birth weight predicted faster heart rate and higher DBP, but neither heart rate nor DBP appeared to be well-coordinated with baroreflex activity (LF), the principal mechanism for short-term blood pressure regulation. Adult autonomic regulation may be significantly altered in those born extremely preterm.
极低出生体重（ELBW；<1000克）的婴儿自主神经功能会发生改变，但我们对这些改变在成年期如何表现知之甚少。我们研究了60名出生时极低体重且无重大神经感觉障碍的参与者（年龄22 - 26岁）以及79名正常出生体重（NBW；>2500克）的对照组中，出生体重与静息心率（R - R间期）、高频（HF）和低频（LF）心率变异性以及收缩压（SBP）和舒张压（DBP）之间的关联。出生体重最小的ELBW参与者的HF显著低于NBW对照组。在两组中，出生体重越高，HF越高。在ELBW幸存者中，出生体重越低，心率越快，DBP越高，但心率和DBP似乎都与压力反射活动（LF）（短期血压调节的主要机制）协调性不佳。极早产儿成年后的自主神经调节可能会发生显著改变。
