吸入性β-肾上腺素能激动剂对新生儿暂时性呼吸急促的影响。
The Effects of Inhaled β-Adrenergic Agonists in Transient Tachypnea of the Newborn.
作者信息
Keleş Esengul, Gebeşçe Arzu, Demirdöven Mehmet, Yazgan Hamza, Baştürk Bülent, Tonbul Alparslan
机构信息
Department of Pediatrics, Fatih University, Istanbul Esengül Keleş, MD, Department of Pediatrics, Fatih University, Istanbul.
出版信息
Glob Pediatr Health. 2016 May 17;3:2333794X16645258. doi: 10.1177/2333794X16645258. eCollection 2016.
Aim. To investigate the efficacy of an inhaled β-adrenergic agonists in transient tachypnea of the newborn (TTN). Method. We retrospectively analyzed a cohort of 51 term infants (Group 1) and 37 term infants (Group 2) monitored in the newborn intensive care unit diagnosed with TTN. Infants in Group 1 received humidified oxygen alone, and infants in Group 2 were administered the inhaled β-2 agonist plus humidified oxygen. Results. TTN clinical respiratory assessment, respiratory rate, oxygen saturation values, need for supplemental oxygen therapy, blood gas PH, PO2, and duration of hospitalization were significantly improved in infants in Group 2 as compared with infants in Group 1 (P < .05). No statistically significant difference was observed with regard to blood glucose, potassium, heart rate, and PCO2 (P > .05). Conclusion. Inhaled β-adrenergic agonist added to humidified oxygen was found to improve clinical and laboratory parameters. We believe that further studies should be conducted with larger groups to demonstrate the efficacy of β-2 agonists in TTN patients.
目的。探讨吸入性β-肾上腺素能激动剂治疗新生儿暂时性呼吸急促（TTN）的疗效。方法。我们回顾性分析了在新生儿重症监护病房监测的51例足月儿（第1组）和37例足月儿（第2组），这些患儿被诊断为TTN。第1组婴儿仅接受湿化氧气，第2组婴儿接受吸入性β-2激动剂加湿化氧气治疗。结果。与第1组婴儿相比，第2组婴儿的TTN临床呼吸评估、呼吸频率、血氧饱和度值、补充氧气治疗需求、血气pH值、PO2以及住院时间均有显著改善（P < 0.05）。在血糖、钾、心率和PCO2方面未观察到统计学显著差异（P > 0.05）。结论。发现加用湿化氧气的吸入性β-肾上腺素能激动剂可改善临床和实验室参数。我们认为应进行更大规模的研究以证明β-2激动剂对TTN患者的疗效。
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