Behzadi Cyrus, Welsch Goetz H, Laqmani Azien, Henes Frank O, Kaul Michael G, Schoen Gerhard, Adam Gerhard, Regier Marc
1 Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.
2 Department of Sports Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.
Br J Radiol. 2016 Aug;89(1064):20151075. doi: 10.1259/bjr.20151075. Epub 2016 Jun 23.
To quantitatively assess the immediate effect of long-distance running on T2 and T2* relaxation times of the articular cartilage of the knee at 3.0 T in young healthy adults.
30 healthy male adults (18-31 years) who perform sports at an amateur level underwent an initial MRI at 3.0 T with T2 weighted [16 echo times (TEs): 9.7-154.6 ms] and T2* weighted (24 TEs: 4.6-53.6 ms) relaxation measurements. Thereafter, all participants performed a 45-min run. After the run, all individuals were immediately re-examined. Data sets were post-processed using dedicated software (ImageJ; National Institute of Health, Bethesda, MD). 22 regions of interest were manually drawn in segmented areas of the femoral, tibial and patellar cartilage. For statistical evaluation, Pearson product-moment correlation coefficients and confidence intervals were computed.
Mean initial values were 35.7 ms for T2 and 25.1 ms for T2*. After the run, a significant decrease in the mean T2 and T2* relaxation times was observed for all segments in all participants. A mean decrease of relaxation time was observed for T2 with 4.6 ms (±3.6 ms) and for T2* with 3.6 ms (±5.1 ms) after running.
A significant decrease could be observed in all cartilage segments for both biomarkers. Both quantitative techniques, T2 and T2*, seem to be valuable parameters in the evaluation of immediate changes in the cartilage ultrastructure after running.
This is the first direct comparison of immediate changes in T2 and T2* relaxation times after running in healthy adults.
定量评估长跑对年轻健康成年人膝关节软骨在3.0 T磁场下T2和T2*弛豫时间的即时影响。
30名健康成年男性（18 - 31岁），业余水平运动者，在3.0 T磁场下接受首次MRI检查，进行T2加权成像（16个回波时间（TEs）：9.7 - 154.6 ms）和T2*加权成像（24个TEs：4.6 - 53.6 ms）弛豫测量。此后，所有参与者进行45分钟的跑步。跑步后，所有个体立即重新检查。数据集使用专用软件（ImageJ；美国国立卫生研究院，马里兰州贝塞斯达）进行后处理。在股骨、胫骨和髌软骨的分割区域手动绘制22个感兴趣区域。为进行统计评估，计算了Pearson积矩相关系数和置信区间。
T2的平均初始值为35.7 ms，T2为25.1 ms。跑步后，所有参与者所有节段的T2和T2弛豫时间均值均显著下降。跑步后，T2弛豫时间平均下降4.6 ms（±3.6 ms），T2*弛豫时间平均下降3.6 ms（±5.1 ms）。
两种生物标志物在所有软骨节段均观察到显著下降。T2和T2*这两种定量技术似乎都是评估跑步后软骨超微结构即时变化的有价值参数。
这是首次对健康成年人跑步后T2和T2*弛豫时间的即时变化进行直接比较。
