运用LMS法建立中国正常人群血清胸苷激酶1水平的标准化百分位数曲线及参考区间

Standardized Centile Curves and Reference Intervals of Serum Thymidine Kinase 1 Levels in a Normal Chinese Population Using the LMS Method.

作者信息

Cao Xia, Zhou Jiansong, Chen Zhiheng

机构信息

1 Health Management Center, the Third Xiangya Hospital, Central South University , Changsha, Hunan Province, China .

2 Mental Health Institute, the Second Xiangya Hospital, Central South University , Changsha, Hunan Province, China .

出版信息

Genet Test Mol Biomarkers. 2016 Aug;20(8):445-50. doi: 10.1089/gtmb.2015.0288. Epub 2016 Jun 23.

DOI:10.1089/gtmb.2015.0288

PMID:27337028

Abstract

AIMS

The aim of the present study was to re-establish a set of normative data for serum thymidine kinase 1 (STK1) for the Chinese population.

METHODS

The study included 14,960 Chinese subjects (9586 males and 5374 females) from 20 to 79 years old. Subjects suffering from diseases that could affect STK1 levels were excluded. STK1 was measured by a sensitive chemiluminescence dot blot assay. The reference intervals were calculated using the LMS method.

RESULTS

Peak thymidine kinase 1 (TK1) serum levels were observed at 20 years of age for both genders. After the age of 20 years, serum TK1 levels decreased slowly from 0.51 to 0.36 pM, reaching a plateau to a mean of 0.35 pM in late adulthood. The mean pretreatment STK1 Z-scores in patients with solid malignant tumors obtained from related studies for cancers were 0.01 ± 0.99 (males, -0.07 ± 0.97; females, 0.09 ± 1.02).

CONCLUSIONS

The present study established age- and gender-specific normative STK1 data for the Chinese population and showed the utility of these references for screening patients with solid malignant tumors.

摘要

目的

本研究旨在重新建立中国人群血清胸苷激酶1（STK1）的一组规范数据。

方法

该研究纳入了14960名年龄在20至79岁之间的中国受试者（9586名男性和5374名女性）。排除患有可能影响STK1水平疾病的受试者。采用灵敏的化学发光斑点印迹法测定STK1。使用LMS方法计算参考区间。

结果

男女两性的胸苷激酶1（TK1）血清水平在20岁时均观察到峰值。20岁以后，血清TK1水平从0.51缓慢下降至0.36 pM，在成年后期达到平均0.35 pM的平台期。从相关癌症研究中获得的实体恶性肿瘤患者的预处理前STK1 Z评分均值为0.01±0.99（男性，-0.07±0.97；女性，0.09±1.02）。