Dexter D T, Jenner P, Marsden C D
University Department of Neurology, Institute of Psychiatry, London, U.K.
Mov Disord. 1989;4(2):176-82. doi: 10.1002/mds.870040209.
Following the intravenous infusion of oxyferriscorbone into the tail vein of the rat, the blood and brain metal ion content was measured over the following 72 h period. Administration of oxyferriscorbone increased the total iron content of blood for up to 24 h following intravenous infusion. In contrast, there was no increase in the total iron content of the cerebellum or striatum. Overall, there was no change in total zinc or copper content of the blood or brain following oxyferriscorbone administration. The effect of oxyferriscorbone in Parkinson's disease may not be related to any alteration in total iron content of the brain.
将氧铁骨化醇经尾静脉注入大鼠体内后，在接下来的72小时内测量血液和脑内金属离子含量。静脉输注氧铁骨化醇后，血液中的总铁含量在长达24小时内升高。相比之下，小脑或纹状体的总铁含量没有增加。总体而言，给予氧铁骨化醇后，血液或脑内的总锌或总铜含量没有变化。氧铁骨化醇对帕金森病的作用可能与脑内总铁含量的任何改变无关。
