Graduate School of Natural Science and Technology, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.
JST, PRESTO , 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
J Am Chem Soc. 2016 Jul 6;138(26):8064-7. doi: 10.1021/jacs.6b04125. Epub 2016 Jun 27.
Mixing cyclic pentagonal pillar[5]quinone with cyclic hexagonal pillar[6]arene in a 12:20 molar feed ratio resulted in spontaneous production of vesicles, while assembly of pillar[6]arene and pillar[5]quinone alone produced hexagonal disks and wires, respectively. Incorporation of pentagonal pillar[5]quinone rings into hexagonal pillar[6]arene sheets gave curvature and contributed to the formation of vesicles. Conventional vesicles are generally synthesized by assembly of amphiphilic molecules containing hydrophobic and hydrophilic parts. Therefore, the co-assembly of pentagonal and hexagonal molecules to obtain spherical vesicles demonstrated in this study is a new concept based on geometric design.
将环状五聚亚甲基苯醌与环状六聚亚甲基苯并环丁烯以 12:20 的摩尔进料比混合，会自发产生囊泡，而单独组装苯并环丁烯和苯醌则分别产生六方盘和线。将五聚亚甲基苯醌环纳入六聚亚甲基苯并环丁烯片层赋予了曲率，并有助于囊泡的形成。常规囊泡通常是通过含有疏水和亲水部分的两亲分子的组装来合成的。因此，本研究中通过五聚和六聚分子的共组装获得球形囊泡的方法是基于几何设计的新概念。
