Hadanny Amir, Efrati Shai
a The Sagol Center for Hyperbaric Medicine and Research , Assaf Harofeh Medical Center , Zerifin , Israel.
b Sackler School of Medicine , Tel-Aviv University , Tel-Aviv , Israel.
Expert Rev Neurother. 2016 Aug;16(8):875-87. doi: 10.1080/14737175.2016.1205487. Epub 2016 Jul 4.
Persistent post-concussion syndrome caused by mild traumatic brain injury has become a major cause of morbidity and poor quality of life. Unlike the acute care of concussion, there is no consensus for treatment of chronic symptoms. Moreover, most of the pharmacologic and non-pharmacologic treatments have failed to demonstrate significant efficacy on both the clinical symptoms as well as the pathophysiologic cascade responsible for the permanent brain injury. This article reviews the pathophysiology of PCS, the diagnostic tools and criteria, the current available treatments including pharmacotherapy and different cognitive rehabilitation programs, and promising new treatment directions. A most promising new direction is the use of hyperbaric oxygen therapy, which targets the basic pathological processes responsible for post-concussion symptoms; it is discussed here in depth.
轻度创伤性脑损伤所致的持续性脑震荡后综合征已成为发病和生活质量低下的主要原因。与脑震荡的急性护理不同，对于慢性症状的治疗尚无共识。此外，大多数药物和非药物治疗在临床症状以及导致永久性脑损伤的病理生理级联反应方面均未显示出显著疗效。本文综述了脑震荡后综合征的病理生理学、诊断工具和标准、当前可用的治疗方法，包括药物治疗和不同的认知康复方案，以及有前景的新治疗方向。一个最有前景的新方向是使用高压氧治疗，其针对导致脑震荡后症状的基本病理过程；本文将对此进行深入讨论。
