Kahraman Feyza Ustabaş, Torun Emel, Osmanoğlu Nurcan Keskin, Oruçlu Suera, Özer Ömer Faruk
Department of Pediatrics, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey.
Department of Biochemistry, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey.
Pediatr Int. 2017 Jan;59(1):68-73. doi: 10.1111/ped.13073. Epub 2016 Nov 21.
Exposure to secondhand smoke is too common in many countries. The mechanism of the detrimental effects of passive smoking on childhood health, however, is poorly described. The purpose of this study was therefore to examine the effect of passive smoking on total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase-1 in children compared with healthy non-passive smokers.
This study included 40 children and adolescents passively exposed to cigarette smoke (as verified on urine cotinines) and 40 age- and gender-matched healthy controls not regularly exposed to cigarette smoke. TAS, TOS, and paraoxonase-1 were all measured, and the oxidative stress index (OSI) calculated for each child to determine the degree of oxidative stress.
Age and gender distribution were not statistically different between the two groups (P = 0.619 and 0.712, respectively). Urine cotinine/creatinine was significantly higher in the passive smoking group (127.89 ± 57.14 ng/mL) compared with the controls (5.05 ± 16.66 ng/mL; P < 0.001). TAS was not different between the two groups (P = 0.767), but TOS and OSI were significantly higher for the passive smoke-exposed children (P < 0.001), and serum paraoxonase-1 was significantly lower than in the controls (P = 0.047).
Secondhand smoke exposure is associated with increased oxidative stress and decreased paraoxonase-1 without any change in antioxidant status.
在许多国家，接触二手烟的情况非常普遍。然而，被动吸烟对儿童健康产生有害影响的机制却鲜有描述。因此，本研究的目的是比较被动吸烟儿童与健康非被动吸烟者在总抗氧化状态（TAS）、总氧化状态（TOS）和对氧磷酶-1方面的差异。
本研究纳入了40名被动接触香烟烟雾的儿童和青少年（通过尿可替宁检测证实）以及40名年龄和性别匹配、未经常接触香烟烟雾的健康对照者。测量了所有受试者的TAS、TOS和对氧磷酶-1，并计算每个儿童的氧化应激指数（OSI）以确定氧化应激程度。
两组之间的年龄和性别分布无统计学差异（P分别为0.619和0.712）。被动吸烟组的尿可替宁/肌酐水平（127.89±57.14 ng/mL）显著高于对照组（5.05±16.66 ng/mL；P<0.001）。两组之间的TAS无差异（P = 0.767），但被动吸烟儿童的TOS和OSI显著更高（P<0.001），且血清对氧磷酶-1显著低于对照组（P = 0.047）。
二手烟暴露与氧化应激增加和对氧磷酶-1降低有关，而抗氧化状态无任何变化。
