尿路致病性大肠杆菌相关外毒素。
Uropathogenic Escherichia coli-Associated Exotoxins.
机构信息
Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706.
出版信息
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.UTI-0011-2012.
Abstract
Escherichia coli are a common cause of infectious disease outside of the gastrointestinal tract. Several independently evolved E. coli clades are common causes of urinary tract and bloodstream infections. There is ample epidemiological and in vitro evidence that several different protein toxins common to many, but not all, of these strains are likely to aid the colonization and immune-evasion ability of these bacteria. This review discusses our current knowledge and areas of ignorance concerning the contribution of the hemolysin; cytotoxic-necrotizing factor-1; and the autotransporters, Sat, Pic, and Vat, to extraintestinal human disease.
摘要
大肠杆菌是胃肠道外感染性疾病的常见病原体。有几个独立进化的大肠杆菌进化枝是尿路感染和血流感染的常见原因。有充分的流行病学和体外证据表明，这些菌株中许多（但不是全部）共同存在的几种不同的蛋白毒素可能有助于这些细菌的定植和免疫逃避能力。本文综述了我们目前对溶血素、细胞毒性坏死因子-1以及自转运蛋白 Sat、Pic 和 Vat 对人类肠道外疾病的贡献的了解和未知领域。
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本文引用的文献
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The repeat-in-toxin family member TosA mediates adherence of uropathogenic Escherichia coli and survival during bacteremia.重复毒素家族成员 TosA 介导尿路致病性大肠杆菌的黏附及菌血症期间的存活。
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