Normanno Nicola, De Luca Antonella, Gallo Marianna, Chicchinelli Nicoletta, Rossi Antonio
a Cell Biology and Biotherapy Unit , Istituto Nazionale Tumori 'Fondazione G. Pascale'-IRCCS , Naples , Italy.
b Division of Medical Oncology , 'S.G. Moscati' Hospital , Avellino , Italy.
Expert Rev Anticancer Ther. 2016 Aug;16(8):859-67. doi: 10.1080/14737140.2016.1202767. Epub 2016 Jun 30.
Circulating tumor cells (CTCs) can be isolated from the peripheral blood of cancer patients. Several studies to assess the prognostic and/or predictive role of CTCs have been performed in lung cancer patients.
The state-of-the-art of the role of CTCs in lung cancer patients is reviewed and discussed. A structured search of bibliographic databases for peer-reviewed research literature and of main meetings using a focused review question was undertaken. Expert commentary: Although in the revised studies different technologies, cutoffs, patients' populations and statistical approaches have been used, a high CTCs count as prognostic role in small-cell lung cancer is suggested, whereas additional studies are required to confirm this correlation in non-small-cell lung cancer. A reduction in CTCs count is also likely to be correlated with the lung cancer patients' outcome. Large prospective trials need to confirm the prognostic and/or predictive role of CTCs in lung cancer.
循环肿瘤细胞（CTCs）可从癌症患者的外周血中分离出来。已有多项研究评估了CTCs在肺癌患者中的预后和/或预测作用。
对CTCs在肺癌患者中的作用的最新情况进行了综述和讨论。使用重点综述问题对书目数据库中的同行评审研究文献以及主要会议进行了结构化检索。专家评论：尽管在修订研究中使用了不同的技术、临界值、患者群体和统计方法，但提示高CTCs计数在小细胞肺癌中具有预后作用，而在非小细胞肺癌中则需要更多研究来证实这种相关性。CTCs计数的降低也可能与肺癌患者的预后相关。大型前瞻性试验需要证实CTCs在肺癌中的预后和/或预测作用。
