Spaepen M S, Berryman J R, Bodman H A, Kundsin R B, Fencl V
Anesth Analg. 1978 Mar-Apr;57(2):191-6. doi: 10.1213/00000539-197803000-00008.
Over a 2-year period, 600 cultures of fluid in heated nebulizers in use by patients in the Peter Bent Brigham Hospital were performed. The most commonly isolated microorganisms were Pseudomonas and Alcaligenes species. Pseudomonas aeruginosa was never isolated. Three types of heated nebulizers were in use, and their contamination rate was significantly different (45 percent, 21 percent, and 8 percent, respectively; p less than 0.001). In the course of the study, the overall contamination rate decreased from 47 percent to 10 percent. This was mainly due to elmination of the type of heated nebulizer that was most prone to contamination. Five types of currently available large-reservoir nebulizers were inculated with various organisms and growth patterns studied. The various nebulizing equiment differed in its ability to inhibit or eliminate microbial growth; 1 of the heated nebulizers appeared to enhance growth of some of the inoculated bacteria.
在两年时间里，对彼得·本特·布里格姆医院患者使用的加热雾化器中的600份液体培养物进行了检测。最常分离出的微生物是假单胞菌属和产碱菌属。从未分离出铜绿假单胞菌。使用了三种类型的加热雾化器，它们的污染率有显著差异（分别为45%、21%和8%；p<0.001）。在研究过程中，总体污染率从47%降至10%。这主要是由于淘汰了最容易被污染的加热雾化器类型。用各种生物体对接种了五种目前可用的大容量雾化器，并研究了其生长模式。各种雾化设备在抑制或消除微生物生长的能力方面存在差异；其中一种加热雾化器似乎促进了一些接种细菌的生长。
