Jamil Bushra, Bokhari Mohammad Tauseef Mukhtar, Saeed Azhar, Mukhtar Bokhari Mohammad Zahid, Hussain Zakir, Khalid Tayabba, Bukhari Habib, Imran Muhammad, Abbasi Shahid Ahmad
Department of Biosciences, Comsats Institute of Information Technology. Islamabad, Pakistan.
Al-Sayed Hospital (Pvt) Ltd. Rawalpindi.
J Pak Med Assoc. 2016 Jun;66(6):705-9.
To determine the prevalence of bacteraemia in patients with chronic kidney disease, particularly those on dialysis and those who had had renal transplant, and to evaluate resistance among the isolated strains.
The cross-sectional study was conducted at Kidney Centre, Al-Sayyed Hospital, Rawalpindi, Pakistan, from June to December 2014. Samples that displayed positive growth were separated from the rest. The isolates were then identified and screened for extended spectrum beta lactamases and metallo beta lactamases production and other resistance mechanisms by phenotypic method.
Of the 1400 samples, only 46 samples (3.3%) displayed signal for positive growth. The prevalence of extended spectrum beta lactamase (ESBL) producing strains was recorded to be 37%.Carbapenem resistance was witnessed in 15% samples. Whereas, Methicillin-resistant staphylococcus aureus prevalence was detected to be 2%.
Resistance in gram-negative microbes was rising, while it was declining in gram-positive microbes.
确定慢性肾病患者，尤其是透析患者和肾移植患者的菌血症患病率，并评估分离菌株的耐药性。
2014年6月至12月在巴基斯坦拉瓦尔品第赛义德医院肾脏中心进行了横断面研究。将显示阳性生长的样本与其他样本分开。然后通过表型方法对分离株进行鉴定，并筛选超广谱β-内酰胺酶和金属β-内酰胺酶的产生以及其他耐药机制。
在1400个样本中，只有46个样本（3.3%）显示阳性生长信号。产超广谱β-内酰胺酶（ESBL）菌株的患病率记录为37%。15%的样本中观察到碳青霉烯耐药。而耐甲氧西林金黄色葡萄球菌的患病率检测为2%。
革兰氏阴性微生物的耐药性在上升，而革兰氏阳性微生物的耐药性在下降。
