丹麦 1994-2011 年感染性心内膜炎发病率的上升。

The increasing incidence of infective endocarditis in Denmark, 1994-2011.

机构信息

Department of Cardiology, Gentofte Hospital, Kildegaardsvej 28, 2900 Hellerup, Denmark; Department of Internal Medicine, Kolding Hospital, Skovvangen 2-8, 6000 Kolding, Denmark.

Department of Cardiology, Gentofte Hospital, Kildegaardsvej 28, 2900 Hellerup, Denmark.

出版信息

Eur J Intern Med. 2016 Nov;35:95-99. doi: 10.1016/j.ejim.2016.05.021. Epub 2016 Jun 21.

DOI:10.1016/j.ejim.2016.05.021

PMID:27339641

Abstract

BACKGROUND

Little updated population-based evidence exists of temporal trends in infective endocarditis (IE).

METHODS

For the 1994-2011 period, we used Danish nationwide registries to identify cases with first-time IE and to estimate the population size. We calculated the incidence rate of IE in 3-year intervals. To evaluate time trends in incidence, we used the 1994-1996 period as reference and computed incidence ratios and 95% confidence intervals (CI) as the incidence in each of the subsequent 3-year intervals divided by the incidence in the reference period.

RESULTS

We identified 5486 incident IE patients (65% men) and the mean age at diagnosis was 63years. Men tended to be younger at diagnosis than women; 62years vs. 65years. Mean age at IE diagnosis steadily increased from 57years in 1994-1996 to 65years in 2009-2011. The IE incidence rate increased from 3.93 per 100,000 person-years in 1994-1996 to 7.55 per 100,000 person-years in 2009-2011, corresponding to an incidence ratio of 1.92 (95% CI: 1.74-2.12). The increase in incidence over time was more pronounced in men (2.28, 95% CI: 2.02-2.59) than in women (1.39, 95% CI: 1.18-1.64). We observed no increase in incidence over time for subjects younger than 50years, whereas the incidence increased substantially over time for elderly patients, with the highest incidence ratio of 3.38 (95% CI: 2.55-4.52) for patients more than 80years at IE onset.

CONCLUSION

The incidence of IE increased over time particularly among men and for the older age groups.

摘要

背景

目前有关感染性心内膜炎（IE）的时间趋势的更新的基于人群的证据很少。

方法

在 1994-2011 年期间，我们使用丹麦全国性登记处来确定首次 IE 病例并估计人口规模。我们计算了每 3 年的 IE 发生率。为了评估发病率的时间趋势，我们将 1994-1996 年作为参考期，并计算了发病率比和 95%置信区间（CI），即每个后续 3 年期间的发病率除以参考期的发病率。

结果

我们确定了 5486 例新发 IE 患者（65%为男性），诊断时的平均年龄为 63 岁。男性诊断时的年龄比女性小；分别为 62 岁和 65 岁。IE 诊断的平均年龄从 1994-1996 年的 57 岁稳步上升到 2009-2011 年的 65 岁。IE 发病率从 1994-1996 年的每 100000 人年 3.93 例上升到 2009-2011 年的每 100000 人年 7.55 例，相应的发病率比为 1.92（95%CI：1.74-2.12）。随着时间的推移，男性的发病率上升更为明显（2.28，95%CI：2.02-2.59），而女性的发病率上升则不明显（1.39，95%CI：1.18-1.64）。我们没有观察到 50 岁以下人群的发病率随时间的推移而增加，而老年患者的发病率则显著上升，IE 发病时年龄超过 80 岁的患者发病率比最高，为 3.38（95%CI：2.55-4.52）。