Deshpande Pooja, Lucas Michaela, Brunt Samantha, Lucas Andrew, Hollingsworth Peter, Bundell Christine
School of Anatomy, Physiology and Human Biology, University of Western Australia, Nedlands, WA, Australia.
Department of Clinical Immunology, PathWest Laboratory Medicine, QE II Medical Centre, Nedlands, WA, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, Nedlands, WA, Australia; School of Medicine and Pharmacology, Harry Perkins Building, University of Western Australia, Nedlands, WA, Australia.
Pathology. 2016 Aug;48(5):483-90. doi: 10.1016/j.pathol.2016.03.014. Epub 2016 Jun 20.
The aim of this study was to determine the prevalence and type of autoantibodies in a general Australian population cohort. Samples collected from 198 individuals included in a cross sectional Busselton Health Study were tested using autoantibody assays routinely performed at Clinical Immunology, PathWest Laboratory Medicine, Western Australia. At least one autoantibody was detected in 51.5% of individuals (males = 45.1%, females = 58.3%). The most frequently detected serum autoantibodies were anti-beta-2-glycoprotein I (12.1%) followed by anti-smooth muscle (11.6%) and anti-thyroid peroxidase (8.6%). Vasculitis associated anti-neutrophil cytoplasmic antibodies were present in 5.1%, while anti-nuclear antibodies were detected in 8.6% of individuals. Notably, 65% of positive results were detected at low levels with the exception of anti-myeloperoxidase and anti-beta 2 glycoprotein I IgG antibodies. Autoantibodies are commonly detected at low levels in a predominantly Australian or European population cohort. No large Australian study has yet provided these data for contemporary routine tests. This paper gives important information on the background frequency of autoantibodies in the general population. Due to the nature of this study we are unaware of whether these individuals have subsequently developed an autoimmune disease, however this was not clinically diagnosed at the time of sample collection.
本研究的目的是确定澳大利亚普通人群队列中自身抗体的患病率和类型。从纳入巴瑟尔顿健康横断面研究的198名个体采集的样本，采用西澳大利亚PathWest实验室医学临床免疫学常规进行的自身抗体检测方法进行检测。在51.5%的个体中检测到至少一种自身抗体（男性=45.1%，女性=58.3%）。最常检测到的血清自身抗体是抗β2糖蛋白I（12.1%），其次是抗平滑肌抗体（11.6%）和抗甲状腺过氧化物酶抗体（8.6%）。与血管炎相关的抗中性粒细胞胞浆抗体阳性率为5.1%，抗核抗体在8.6%的个体中被检测到。值得注意的是，除抗髓过氧化物酶和抗β2糖蛋白I IgG抗体外，65%的阳性结果是在低水平检测到的。在以澳大利亚人或欧洲人为主的人群队列中，自身抗体通常在低水平被检测到。澳大利亚尚未有大型研究提供当代常规检测的这些数据。本文给出了普通人群中自身抗体背景频率的重要信息。由于本研究的性质，我们不知道这些个体随后是否发展为自身免疫性疾病，但在样本采集时未临床诊断为此病。
