兔模型中收获的腘绳肌腱组织再生的诱导
Inducement of tissue regeneration of harvested hamstring tendons in a rabbit model.
作者信息
Tabuchi K, Soejima T, Murakami H, Noguchi K, Shiba N, Nagata K
机构信息
Department of Orthopaedic Surgery, Kurume University Medical Center, Kokubu-machi 155-1, Kurume 839-0863, Japan
Institute of Health and Sports Science, Kurume University, Mii-machi 1635, Kurume 839-8502, Japan.
出版信息
Bone Joint Res. 2016 Jun;5(6):247-52. doi: 10.1302/2046-3758.56.2000585.
OBJECTIVES
The objective of this study was to determine if the use of fascia lata as a tendon regeneration guide (placed into the tendon canal following harvesting the semitendinosus tendon) would improve the incidence of tissue regeneration and prevent fatty degeneration of the semitendinosus muscle.
MATERIALS AND METHODS
Bilateral semitendinosus tendons were harvested from rabbits using a tendon stripper. On the inducing graft (IG) side, the tendon canal and semitendinosus tibial attachment site were connected by the fascia lata, which was harvested at the same width as the semitendinosus tendon. On the control side, no special procedures were performed. Two groups of six rabbits were killed at post-operative weeks 4 and 8, respectively. In addition, three healthy rabbits were killed to obtain normal tissue. We evaluated the incidence of tendon tissue regeneration, cross-sectional area of the regenerated tendon tissue and proportion of fatty tissue in the semitendinosus muscle.
RESULTS
At post-operative week 8, the distal end of the regenerated tissue reached the vicinity of the tibial insertion on the control side in two of six specimens. On the IG side, the regenerated tissue maintained continuity with the tibial insertion in all specimens. The cross-sectional area of the IG side was significantly greater than that of the control side. The proportion of fatty tissue in the semitendinosus muscle on the IG side was comparable with that of the control side, but was significantly greater than that of the normal muscle.
CONCLUSIONS
Tendon tissue regenerated with the fascia lata graft was thicker than naturally occurring regenerated tissue. However, the proportion of fatty tissue in the semitendinosus muscle was greater than that of normal muscle.Cite this article: K. Tabuchi, T. Soejima, H. Murakami, K. Noguchi, N. Shiba, K. Nagata. Inducement of tissue regeneration of harvested hamstring tendons in a rabbit model. Bone Joint Res 2016;5:247-252. DOI: 10.1302/2046-3758.56.2000585.
目的
本研究的目的是确定使用阔筋膜作为肌腱再生引导物（在收获半腱肌肌腱后置于肌腱管内）是否会提高组织再生的发生率并防止半腱肌的脂肪变性。
材料与方法
使用肌腱剥离器从兔子身上双侧收获半腱肌肌腱。在诱导移植（IG）侧，肌腱管和半腱肌胫骨附着部位通过阔筋膜相连，阔筋膜的收获宽度与半腱肌肌腱相同。在对照侧，未进行特殊操作。两组各6只兔子分别在术后第4周和第8周处死。此外，处死3只健康兔子以获取正常组织。我们评估了肌腱组织再生的发生率、再生肌腱组织的横截面积以及半腱肌中脂肪组织的比例。
结果
术后第8周，6个对照侧标本中有2个再生组织的远端到达胫骨附着点附近。在IG侧，所有标本中的再生组织与胫骨附着点保持连续。IG侧的横截面积明显大于对照侧。IG侧半腱肌中脂肪组织的比例与对照侧相当，但明显大于正常肌肉。
结论
使用阔筋膜移植再生的肌腱组织比自然再生的组织更厚。然而，半腱肌中脂肪组织的比例大于正常肌肉。引用本文：K. Tabuchi, T. Soejima, H. Murakami, K. Noguchi, N. Shiba, K. Nagata。兔模型中收获的腘绳肌腱组织再生的诱导。骨关节研究2016；5：247 - 252。DOI: 10.1302/2046 - 3758.56.2000585。
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