Nefedova N A, Kharlova O A, Danilova N V, Malkov P G, Gaifullin N M
Russian Medical Academy of Postgraduate Education Ministry of Health of Russia, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.
Lomonosov Moscow State University, Moscow, Russia.
Arkh Patol. 2016 Mar-Apr;78(2):55-63. doi: 10.17116/patol201678255-62.
Angiogenesis is a process of new blood vessels formation. The role of angiogenesis in growth, invasion and metastasis of malignant tumours is nowdays universally recognized. Though, investigation of mechanisms of blood vessels formation and elaboration methods for assessment of tumour angiogenesis are still up-dated. Another important concern are different aspects of usage of immunohistochemical markers of blood vessels endothelium (CD31 and CD34) for assessment of tumour aggressiveness and prognosis. The problems of malignant lymphangiogenesis are also up-to-date. The focus is on methods of immunohistochemical visualization of forming lymphatic vessels, role of podoplanin, the most reliable marker of lymphatic vessels, in their identification, and formulization of the main criteria for lymphangiogenesis estimation, its correlation with metastatic activity and prognostic potential. Studying of angiogenesis and lymph angiogenesis in malignant tumors is important and challenging direction for researching tumour progression and invention of antiangiogenic therapy.
血管生成是新血管形成的过程。血管生成在恶性肿瘤生长、侵袭和转移中的作用如今已得到普遍认可。然而，血管形成机制的研究以及评估肿瘤血管生成的精细方法仍在不断更新。另一个重要问题是使用血管内皮免疫组化标记物（CD31和CD34）评估肿瘤侵袭性和预后的不同方面。恶性淋巴管生成问题也很前沿。重点在于形成淋巴管的免疫组化可视化方法、淋巴管最可靠标记物血小板反应蛋白1在其识别中的作用，以及淋巴管生成评估主要标准的制定、其与转移活性和预后潜力的相关性。研究恶性肿瘤中的血管生成和淋巴管生成是肿瘤进展研究和抗血管生成治疗发明的重要且具有挑战性的方向。
