Okuhata Y, Yasukochi H, Lee K, Murakami K, Tanibe M, Koga M, Shirato M, Nagai J, Kuniyasu Y
Nihon Igaku Hoshasen Gakkai Zasshi. 1989 Jan 25;49(1):35-41.
Sixty cases of routine contrast enhanced CT were analyzed about the utilities of positive pressure drip infusion method using high concentration contrast media 350 mgI/ml, 100 ml. They were divided into three groups and each twenty cases were received positive pressure drip infusion method using Iohexol 350 mg/ml, 100 ml (350PP), positive pressure drip infusion method using Iohexol 300 mgI/ml, 100 ml (300PP) or conventional drip infusion method using Iohexol 300 mgI/ml, 100 ml (300DI). Enhancement effects of the liver parenchyma, the aorta and the spleen at upper, middle and lower levels of the liver were evaluated with increased attenuation on pre- and postcontrast CT. And intrahepatic contrast was evaluated with attenuation difference between liver parenchyma and intrahepatic vessels on postcontrast CT. In result, 300PP kept better enhancement effects and obtained better intrahepatic contrast than 300DI at the each level of the liver, and 350PP was still better than 300PP. The analysis of relationship between intrahepatic contrast and body weight suggested that 300PP was the optimal choice for the cases with 40-50 kg body weight and 350PP was for the ones with 50-60 kg as the infusion method of routine contrast enhanced CT. And the dose of contrast media seemed to be more needed for the cases over 60 kg body weight. 350PP and 300PP were concluded as useful, safe and simple methods for routine contrast enhanced CT of the liver.
分析了60例行常规对比增强CT检查的病例，这些病例使用350mgI/ml、100ml的高浓度对比剂采用正压滴注法。将它们分为三组，每组20例，分别接受使用350mg/ml、100ml碘海醇的正压滴注法（350PP）、使用300mgI/ml、100ml碘海醇的正压滴注法（300PP）或使用300mgI/ml、100ml碘海醇的常规滴注法（300DI）。通过对比增强CT前后肝脏实质、主动脉和脾脏的衰减增加来评估肝脏上、中、下层面的增强效果。并通过对比增强CT上肝脏实质与肝内血管之间的衰减差异来评估肝内对比情况。结果显示，在肝脏的各个层面，300PP比300DI保持了更好的增强效果并获得了更好的肝内对比，且350PP比300PP更好。肝内对比与体重关系的分析表明，作为常规对比增强CT的滴注方法，300PP是体重40 - 50kg患者的最佳选择，350PP是体重50 - 60kg患者的最佳选择。对于体重超过60kg的患者似乎更需要对比剂剂量。350PP和300PP被认为是肝脏常规对比增强CT有用、安全且简单的方法。
