Kodaira T, Shimamoto K, Hirota H, Itoh S, Itoh K, Kamata N, Ishigaki T, Ikeda M
Department of Radiology, Nagoya University, School of Medicine.
Nihon Igaku Hoshasen Gakkai Zasshi. 1995 Feb;55(3):138-44.
In 99 examinations of 89 patients, we took CT images of the chest after administering one of three concentrations of contrast medium (iohexol 140 mgI/ml, 240 mgI/ml, 300 mgI/ml) to determine the optimal iodo-concentration for intravenous contrast enhancement in spiral CT. Attenuation values of the superior vena cava, ascending aorta, descending aorta, and pulmonary artery were measured to evaluate the degree of contrast enhancement. Five radiologists judged the image quality by scoring factors such as vascular opacification, delineation of the lung and chest wall, detectability of calcification, lymphadenopathy and pulmonary nodules, and the presence of artifacts. The relationships between the iodo-concentration and the scores were analyzed statistically. The higher the iodo-concentration of the contrast medium administered, the stronger the vascular structures were opacified. There was also a concurrent improvement in the detection of lymphadenopathy. However, artifacts appeared on the administration route as a result of the high-concentration contrast medium, and the image quality was degraded. Among the three groups, iohexol 240 mgI/ml exhibited the best performance, namely, good image quality, so that a high degree of contrast enhancement of the vasculature was obtained with few artifacts due to the contrast medium. However, we believe that iohexol 140 mgI/ml presents no significant problems in routine studies.
在对89例患者进行的99次检查中，我们在给予三种浓度（碘海醇140 mgI/ml、240 mgI/ml、300 mgI/ml）之一的造影剂后拍摄胸部CT图像，以确定螺旋CT静脉造影增强的最佳碘浓度。测量上腔静脉、升主动脉、降主动脉和肺动脉的衰减值，以评估造影增强程度。五位放射科医生通过对血管显影、肺和胸壁的轮廓、钙化的可检测性、淋巴结病和肺结节以及伪影的存在等因素进行评分来判断图像质量。对碘浓度与评分之间的关系进行统计学分析。给予的造影剂碘浓度越高，血管结构显影越强。淋巴结病的检测也同时得到改善。然而，高浓度造影剂导致给药途径出现伪影，图像质量下降。在三组中，碘海醇240 mgI/ml表现最佳，即图像质量良好，因此在造影剂产生较少伪影的情况下获得了血管的高度造影增强。然而，我们认为碘海醇140 mgI/ml在常规研究中没有明显问题。
