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使用自膨式支架治疗恶性大肠梗阻。深入探讨肠穿孔和手术失败情况。

Managing Malignant Colorectal Obstruction with Self-Expanding Stents. A Closer Look at Bowel Perforations and Failed Procedures.

作者信息

Gleditsch D, Søreide O K, Nesbakken A

机构信息

Department of Gastrointestinal Surgery, Vestre Viken Health Trust, Drammen Hospital, 3004, Drammen, Norway.

University of Oslo, Oslo, Norway.

出版信息

J Gastrointest Surg. 2016 Sep;20(9):1643-9. doi: 10.1007/s11605-016-3186-z. Epub 2016 Jun 24.

Abstract

Stent treatment of large bowel obstruction is still controversial. There are concerns regarding complications, particularly bowel perforation, as well as long-term outcome in curable patients. Through a 10-year retrospective study, we have evaluated efficacy, complications, delay in surgical interventions and stent patency in cases of palliative treatment. We treated 183 patients, 85 as bridge to surgery and 98 as definitive, palliative treatment. At presentation, 58 % of patients had advanced local or metastatic disease. Seventeen patients required more than one stent insertion. The total number of procedures was 213. We recorded technical and clinical success or failure, complications, necessity of restenting or surgical intervention, mortality and stent patency in the palliation group. Stenting was clinically successful in 89 % of the bridge to surgery group and 86 % of the palliative group. Complications occurred in 7 %, including 12 perforations. Six patients suffered an early perforation, of which two died. Half of the six late perforations were silent. Procedure related mortality was 1 %. The clinical success rate was high in both the palliative and bridge to surgery setting. The complication rate was low, and the sum of early and late perforations was 5.6 %. Procedure related mortality was low.

摘要

大肠梗阻的支架治疗仍存在争议。人们担心并发症,尤其是肠穿孔,以及可治愈患者的长期预后。通过一项为期10年的回顾性研究,我们评估了姑息治疗病例的疗效、并发症、手术干预延迟和支架通畅情况。我们治疗了183例患者,其中85例作为手术桥梁,98例作为确定性姑息治疗。就诊时,58%的患者患有晚期局部或转移性疾病。17例患者需要插入多个支架。手术总数为213例。我们记录了姑息治疗组的技术和临床成功或失败、并发症、再次置入支架或手术干预的必要性、死亡率和支架通畅情况。在手术桥梁组中,89%的患者支架置入临床成功,在姑息治疗组中这一比例为86%。并发症发生率为7%,包括12例穿孔。6例患者发生早期穿孔,其中2例死亡。6例晚期穿孔中有一半是无症状的。手术相关死亡率为1%。在姑息治疗和手术桥梁治疗中,临床成功率都很高。并发症发生率低,早期和晚期穿孔总数为5.6%。手术相关死亡率低。

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